Promethazine

Question 1

Promethazine

Class

Answer 1

• Antihistamine

Question 2

Promethazine

MOA

Answer 2

• H1 receptor antagonist
• Blocks action of histamine
• Sedative qualities
• Antiemetic qualities
• Antimotion qualities
• Anticholinergic qualities
• Potentiates effects of narcotics to induce analgesia

Question 3

Promethazine

Indications

Answer 3

• Nausea
• Vomiting
• Motion sickness
• Sedation for pt’s in labor
• Potentiation of analgesic effects of narcotics

Question 4

Promethazine

Contraindications

Answer 4

• Hypersensitivity
• Coma
• CNS depressed pt’s from:
  
  • alcohol
  • barbiturates
  • narcotcs
  • Reye’s syndrome

Question 5

Promethazine

Adverse reactions

Answer 5

• Sedation
• Dizziness
• Impairment of mental & physical ability
• Arrhythmias
• N/V
• Hyperexcitability
• Hallucinations
• Convulsions
• Sudden death when used in children

Question 6

Promethazine

Drug Interactions

Answer 6

• Additive with other CNS depressants
• Increased extrapyramidal effects with MAOI’s

Question 7

Promethazine

Dosage

Answer 7

• Adult:
  
  • 12.5 - 25 mg IV, deep IM, PO, rectally
• Ped (greater than 2 yo):
  
  • 0.25 - 0.5 mg/kg IM

Question 8

Promethazine

Duration of action

Answer 8

• Onset IV: Immediate
• Peak: 30-60 min
• Duration: 4-6 hrs

Question 9

Promethazine

Special Considerations

Answer 9

• Preg Cat: C
• Use caution in pt’s that have:
  
  • asthma
  • peptic ulcer disease
  • bone marrow suppression
• Do not use in children with vomiting of unknown etiology
• Avoid-intra-arterial injection
• IM is preferred route