Lorazepam (Ativan) Flashcards

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1
Q

Lorazepam (Ativan)

Class

A
  • Benzodiazepine
  • Sedative
  • Anticonvulsant
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2
Q

Lorazepam (Ativan)

Mechanism of action

A
  • Anticonvulsant
  • Suppresses propagation of sz activity
  • Anxiolytic
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3
Q

Lorazepam (Ativan)

Indications

A
  • Initial control of status epilepticus or severe recurrent sz
  • Severe anxiety
  • Sedation
  • OK for head injury
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4
Q

Lorazepam (Ativan)

Contraindications

A
  • Acute narrow angle glaucoma
  • Coma
  • Shock
  • Suspected drug abuse
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5
Q

Lorazepam (Ativan)

Adverse reactions

A
  • Resp depression & apnea
  • Drowsiness, sedation, confusion
  • Hypotension, bradycardia
  • Delerium, restlessness
  • Psychomotor impairment
  • Ataxia
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6
Q

Lorazepam (Ativan)

Drug interactions

A
  • May precipitate CNS depression if pt is already taking CNS depressants
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7
Q

Lorazepam (Ativan)

Dosage & administration

A

When given IV or IO, must dilute with equal volume of NS.

  • Adult:
    • 2-4 mg slow IV @ 2mg/min or IM
      • May repeat in 15-20 min to max dose of 8 mg
    • For sedation: 0.05 mg/kg IM up to 4 mg IM
  • Ped:
    • 0.05 - 0.20 mg/kg slow IV, IO slowly over 2 min or IM
      • May repeat in 15-20 min to max dose of 0.2 mg/kg
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8
Q

Lorazepam (Ativan)

Duration

A
  • Onset: 1-5 min
  • Peak: Varies
  • Duration: 6-8 hours
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9
Q

Lorazepam (Ativan)

Special considerations

A
  • Pregnancy: Cat D
  • Arterial injection may cause vasospasm and gangrene
  • Monitor BP and resp
  • Have advanced airway ready to go
  • Expires in 6 weeks when not refrigerated
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