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HISTOLOGÍA > The Immune System & Lymphoid Organs > Flashcards

The Immune System & Lymphoid Organs Flashcards

1
Q

Esta formado por una cápsula de tejido conectivo y algunas celulas de musculo liso las cuales rodean a un grupo de linfocitos

A

Ganglio linfático

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2
Q

Cinco o mas linfocitos con cápsula son

A

Ganglio linfático

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3
Q

La cápsula de tejido conectivo de los ganglios linfáticos producen invaginaciones hacia dentro del ganglio que se llamaran

A

Trabeculas en las cuales se apoyan un sistema de fibras reticulares la cual va a servir de apoyo y estructura a todo el ganglio

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4
Q

Dos capas del ganglio linfático

A

Capa medular central

Y una corteza

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5
Q

Formada por vasos sanguíneos y tejido conectivo que conectaran con el hilio

A

Copa medular del ganglio linfático

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6
Q

Donde se encuentran la mayor parte de nódulos o folículos linfoides en los ganglios linfáticos

A

Corteza del ganglio linfático

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7
Q

Acumulación ovoide dentro del ganglio linfático formada por linfocitos B que forman un acumulos de linfocitos

A

Folículo linfoide o nódulo

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8
Q

Folículo linfoide o nódulo cuando se encuentra activa

A

Palidece su centro (centro germinal) y se compactan formando una semiluna en su porción mas externa menos activa

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9
Q

Funciones de los ganglios linfáticos

A

Filtración de partículas extrañas
Fagocitosis de material que produce reacción antígeno-anticuerpo
Proliferación de linfocitos sensibilizados que se convierten en linfoblastos
Recirculacion de linfocitos maduros

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10
Q

La filtración de partículas extrañas como el carbón se puede ver mas evidentemente en

A

Los ganglios peritraqueales y celulas tumorales

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11
Q

Son la fuente de las células plasmaticas (y de ahí anticuerpos para la respuesta humoral) y de los linfocitos cito tóxicos especificos

A

Linfoblastos

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12
Q

Peso del bazo

A

150 gramos

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13
Q

Órgano de forma discoide que se encuentra en el cuadrante superior izquierdo del abdomen con la presencia de una escotadura en su borde anterior

A

Bazo

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14
Q

El bazo se encuentra encapsulado por

A

Una capa delgada de tejido difícilmente desprendible

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15
Q

Dos estructuras que se pueden diferenciar del bazo

A

Pulpa blanca

Pulpa roja

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16
Q

Estructura del bazo que se encuentra formada por el tejido linfoide en el que predominan linfocitos B y que forman los folículos linfoides.

A

Pulpa blanca

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17
Q

Estructura del bazo que se encuentra formada por los eritrocitos y sus conductos contenidos en el bazo

A

Pulpa roja

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18
Q

Los 4 conductos o estructuras vasculares del bazo

A

Una arteria central delgado que no se anastomosa
Cordones esplacnicos de Billroth
Sinusiodes
Linfocitos T

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19
Q

Son pequeños órganos ovoides intercalados con los vasos linfáticos periféricos y por donde termina pasando toda la linfa

A

Ganglios linfáticos

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20
Q

Son venas grandes de pared delgada que drenan a venas pulpares, estas estructuras vasculares se encuentran rodeadas por linfocitos tipo T

A

Los sinusoides

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21
Q

La distribución de la pulpa roja se hace en zonas, siendo la mas externa

A

La marginal

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22
Q

Capa densa de linfocitos acomodada alrededor de los centros germinales

A

Manto

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23
Q

Función del bazo

A

Hasta el momento del nacimiento mielopoyesis

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24
Q

Interviene en la recirculacion de los linfocitos y en la formación de linfocitos y celulas plasmaticas nuevas que intervienen en la respuesta inmune

A

Pulpa blanca del bazo

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25
Q

Interviene en la limpieza de la sangre al secuestrar, fagocitar, y destruir por medio de macrofagos glóbulos rojos, plaquetas y bacterias y sirve como lugar de almacenamiento de plaquetas

A

Pulpa roja

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26
Q

Destrucción de eritrocitos para que se puedan emplear su hierro en la formación de nuevos eritrocitos

A

Hemocateresis

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27
Q

Órgano irregularmente triangular, impar localizado en el mediastino anterior del tórax encapsulada que se forma de la tercera bolsa branquial

A

Timo

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28
Q

Origen del timo

A

Tercera bolsa branquial (del endodermo)

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29
Q

Alberga linfocitos de origen mesenquimatoso

A

Timo

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30
Q

Superficie irregularmente lobular (generalmente dos lóbulos) de color gris rosado y emcapsulado por una delgada capa de tejido conectivo laxo

A

Timo

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31
Q

Peso del timo al momento del nacimiento

A

20 gramos

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32
Q

En el momento de la pubertad, el timo llega pesar

A

35 a 50 gramos

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33
Q

Esta formado por lobulillos de forma poliedrica, separados por tabiques de tejido conectivo, conformada por una corteza con linfocitos T(llamados timocitos), macrofagos, celulas epiteliales y reticulares

A

Timo

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34
Q

La medula del timo tiende a ser más pálida cuando

A

Linfocitos T maduros

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35
Q

Es donde ocurre la selección positiva o negativa de linfocitos

A

Unión de la region corticomedular

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36
Q

A nivel de la médula del timo se encuentra proliferaciones de celulas epiteliales en forma de hojas de cebolla o rosas llamadas

A

Corpúsculos de Hassall

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37
Q

En el timo es el ecargado de la producción de linfocitos T conocido como

A

CD4,(helper) y CD8 (citotóxicos) al igual que elimina los linfocitos maduros que van a diferenciarse entre los antígenos propios de los no propios

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38
Q

Son ganglios linfáticos ubicados a nivel de la laringe y faringe

A

Amígdalas

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39
Q

Las tres amígdalas más importantes son

A

Sublingual, palatina y faringea

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40
Q

Epitelio de la amígdala faringea

A

Epitelio columnar pseudostratificado ciliado o epitelio respiratorio

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41
Q

Amígalas palatina y sublingual tiene un epitelio

A

Epitelio plano estratificado no queratenizado

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42
Q

La amígdala palatina cuenta con

A

Invaginaciones de epitelio que forma criptas donde se acumulan dentritus de alimento y celulas descamadas que a simple vista se ve como puntos blancos sobre la amígdala

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43
Q

Two partially overlapping lines of defense against invaders and/or other abnormal potentially harmful cells

A

Innate immunity and adaptive immunity

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44
Q

Is none specific, involves a wide mechanism, and is evolutionarily older

A

Innate immunity

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45
Q

Aims at specific microbial invaders, is mediated by lymphocytes and antigen-presenting cells APCs

A

Adaptive immunity

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46
Q

The lymphocytes and APCs for adaptive immunity are distributed throughout the body in

A

Blood, lymph, epithelial and connective tissues

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47
Q

Primary lymphoid organs

A

Thymus

Bone marrow

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48
Q

Secondary lymphoid organs

A

Lymph nodes
Spleen
Diffuse lymphoid tissue found in the mucosa

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49
Q

The immune cells located diffusely in the digestive, respiratory, or urogenital mucosae collectively known

A

Mucosa-associated lymphoid tissue MALT

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50
Q

Proliferating B lymphocytes in MALT are arranged in small spherical

A

Lymphoid nodules

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51
Q

Physical barrier, part of innate immunity

A

Skin and mucous membrane located diffusely in the digestive, respiratory, or urogenital that prevent infections

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52
Q

Bacteria, fungi, and parasites that manage to penetrate physical barrier are quickly removed by

A

Neutrophils and other leukocytes in connective tissue

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53
Q

Receptors on leukocytes allow the recognition and binding of surface components of such invaders

A

Toll-like receptors TLR

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54
Q

Destroy various unhealthy host cells, including those infected with virus or bacteria as well as certain potentially tumorigenic cells

A

Natural killer cells

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55
Q

In specific regions lower the pH locally to either kill entering microorganisms directly or inhibit their growth

A

Hydrochloric acid HCl and organic acids

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56
Q

Short cationic polypeptide produced by neutrophils and various epithelial cells that kill bacteria by disrupting the cell wall

A

Defensins

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57
Q

An enzyme made by neutrophils and cells of epithelial barrier which hydrolyzes bacterial cell wall

A

Lysozyme

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58
Q

A system of proteins in blood plasma, mucus, and macrophages that react with bacterial surface components to aid removal of bacteria

A

Complement

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59
Q

Paracrine factors from leukocytes and virus-infected cells that signal NK cells to kill such cells and adjacent cells to resist viral infection

A

Interferons

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60
Q

Such bacterias that Avoid phagocytosis by granulocytes and macrophages of innate immunity by covering their cell walls with a capsule of polysaccharides that inhibits recognition and binding to the phagocytes receptors such as

A

Haemophilus influenzae

Streptococcus pneumonae

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61
Q

Is more specific, slower to respond, and An evolutionarily more recent

A

Adaptive immunity

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62
Q

Are aimed at specific microbial invaders and involve production of … so that a similar response can be mounted very rapidly if that invader ever appears again

A

memory lymphocytes

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63
Q

Immune system communicate with each other primarily vía

A

Cytokines to coordinate defensive measures

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64
Q

A diverse group of peptides and glycoproteins with a paracrine mode of action, such as Chemotaxis, increased mitotic activity in leukocytes, stimulations or supression of lymphocyte activities, stimulate fagocitosis

A

Cytokines

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65
Q

Cytokines induced directed cells movements

A

Chemotaxis

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66
Q

Cytokines have target cells besides immune cells such as

A

Endothelial cells certain autonomic neurons and cells of endocrine system

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67
Q

Cytokines Growth and differentiation factors for leukocytes progenitor cells in bone marrow

A

GM-CSF, M-CSF

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68
Q

Cytokines for Stimulation of inflammation and fever

A

TNF-alpha, TGF - beta, IL-1

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69
Q

Cytokines for stimulation of growth in T lymphocytes and NK cells

A

IL 12

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70
Q

Cytokines for Eosinophils proliferation differentiation and activation

A

IL-5

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71
Q

Cytokines for activation of macrophages

A

Interferons gamma , IL -4

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72
Q

Cytokines for inhibition of macrophages and specific adaptive immune responses

A

IL-10

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73
Q

Chemokines for neutrophils and T lymphocytes

A

IL 8

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74
Q

A molecule that is recognized by cells of the adaptive immune system and elicits a response from these cells, may consistof soluble melecules such as proteins or polysaccharides

A

Antígens

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75
Q

Immune cells recognized and react to small molecular domains of the antígens known as antigenic determinants or

A

Epitopes

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76
Q

The immune response in which lymphocytes are primarily in charge of eliminating the antigen

A

Cellular

77
Q

Immune response in which antibodies are primarily responsible for the response

A

Humoral

78
Q

Is a glycoprotein of the immunoglobulins family that interacts specially with an antigenic determinants

A

Antibody

79
Q

Are secreted by by plasma cells that arise by terminal differentiation of clonaly proliferating B lymphocytes whose receptors recognize and bind specific epitopes

A

Antibodies

80
Q

Antibodies accumulate in

A

Blood plasma and intertitial fluid of gland such as mucous, salivary, and mammary glands

81
Q

Immunoglobulins of all antibody molecules have a common design, consisting of

A

Two identical light chain

Two identical heavy chain bound by disulfide bonds

82
Q

The isolated carboxyl terminal portion of the heavy chain molecules is called the constant

A

Fc region

83
Q

Fc region are recognized by cell surface receptors on

A

Basophils and mast cell

84
Q

The first 110 amino acids near the amino-terminal ends of the light and heavy chains vary widely among different antibody molecules called

A

Variable region

85
Q

The variable portions of one heavy and one light chain Make up anti body’s

A

Antigen-binding site

86
Q

Is the most abundant class representing 75% to 85% of immunoglobulins in blood

A

IgG

87
Q

Highly soluble, stable and cross the placental barrier into the fetal circulation confering passive immunity against certain infections until the newborn’s own adaptive immune system

A

IgG

88
Q

Is present in almost all exocrine secretions as a dimeric form in which the heavy chains of two monomers are united by a polypeptide called the J chain and secretory component a protein bound released by epithelial cells as undergo trancytosis

A

IgA

89
Q

Is produced by plasma cells in mucosae of the digestive, respiratory, and reproductive tracts

A

IgA

90
Q

IgA percentage in the plasma

A

10% - 15%

91
Q

IgA structure is resistant to proteolysis and reacts with microorganisms in

A

Milk, saliva, tears, and mucus coating

92
Q

Constitute 5% to 10% of blood immunoglobulin an exits in a pentameric form united by a J chain

A

IgM

93
Q

First antibody produced in initial immune response, activates complement present in B lymphocyte surface as a monomers

A

IgM

94
Q

Monomer, with An percentage of 0.002% less abundant in the circulation and exits bound at its Fc region to receptors on the surface of mast cells and Basophils, destroys parasitic worms and participate in allergies

A

IgE

95
Q

IgE encounters the antigen-antibody complex trigger the liberation of several biologically substances such as

A

Histamine
Heparin
And leukotrienes

96
Q

Is the least abundant immunoglobulin in plasma 0.001% , are bound to the surface of B lymphocytes where they act as antigen receptor in triggering B cell activation

A

IgM

97
Q

Binding of antigen-binding site of an antibody with antigen causes

A

Neutralization
Agglutination
Precipitation

98
Q

Antibody covers biologically active portion of microbe or toxins

A

Neutralization

99
Q

Antibody cross-links cells forming a clump

A

Agglutination

100
Q

Antibody cross-links circulating particles (toxin) forming an insoluble antigen-antibody complex

A

Precipitation

101
Q

Three important actions of innate immunity

A

Complement activation
Opsonization
NK cells activation

102
Q

Antigen-antibody complexes containing IgG or IgM bind polypeptide of the complement system (a group of 20 proteins produced in the liver) activated by enzymatic reaction , after activation specific complement bind and rupture membranes of invading cells,

A

Complement activation

103
Q

Ability of receptors on macrophages, neutrophils, and Eosinophils to recognize and bind the Fc portions of antibodies attached to the surface of microorganisms, increases the efficiency of phagocytosis

A

Opsonization

104
Q

Antibodies bound to antigen on virus infected cells of the body are recognized by NK cells, which are then activated to kill the infected cell by releasing perforins and granzymes

A

NK cells activation

105
Q

Antigen recognized by lymphocytes are often bound to specialized integral membrane protein complex called

A

Major histocompatibility complex MHC

106
Q

Proteins of both class of MHC are called…, are encoded by genes in large chromosomal loci having very high degrees of allelic varation

A

Human leukocytes antigens (HLAs)

107
Q

Are specialized to recognize both class of MHC proteins and antigens they present

A

T lymphocytes

108
Q

If MHCs on cells of a tissue graft are not similar to those T lymphocytes induce a strong reaction like

A

Are recognized as markers of potentially tumorigenic, infected or abnormal cell they must eliminate

109
Q

MHC class that proteins bind a wide variety of proteosome-derived peptide fragments representing the range of all proteins synthesized in that cell, all nucleated cells produce and expose self-antigen, which T cells recognize as a signal to ignore those cell

A

MHC class I

110
Q

Proteins are synthesized and transported to the cell surface but only in cells of the mononuclear phagocyte system, golgi vesicles with MHC complex fuse with endolydomal vesicles containing antigen ingested at the surface of these cells signaling T lymphocytes and activating their responses against sources of these antigen

A

MHC class II

111
Q

When the donor and the host are the same individual such as a burn patient

A

Autograft

112
Q

Are those involving identical twins

A

Isograft

113
Q

Involves two related or unrelated individuals

A

Homograft

114
Q

Inhibit the action of cytotoxic T cells an immunosupressive drugs

A

Cyclosporins

115
Q

Most specialized antigen-presenting cells APCs are part of the mononuclear phagocyte system including …, that have an expression of MHC class II molecules for presenting peptides of exogenous antigens

A

Macrophages and dendritic cells

116
Q

Both regulate and carry out adaptive immunity

A

Lymphocytes

117
Q

Approximate percentages of B and T cells in thymus

A

T 100%

B 0%

118
Q

Approximate percentages of B and T cells in bone marrow

A

T 10%

B 90%

119
Q

Approximate percentages of B and T cells in spleen

A

T 45%

B 55%

120
Q

Approximate percentages of B and T cells in lymph node

A

T 60%

B 40%

121
Q

Approximate percentages of B and T cells in blood

A

T 70%

B 30%

122
Q

The fibers are produced by fibroblastic

A

Reticular cells

123
Q

Is usually reticular connective tissue filled with large Numbers of lymphocytes

A

Lymphoid tissue

124
Q

In all secundary lymphoid tissue the lymphocytes are supported by a rich reticulin fiber network of type

A

Type III collagen

125
Q

All T lymphocytes have cells receptors, requires costimulation by the

A

TCR and either CD4 or CD8

126
Q

Are long-lived lymphocytes and constitute 75% of the circulating lymphocytes

A

T lymphocytes

127
Q

T lymphocytes recognize antigenic epitopes vía surface protein complex termed

A

T cell receptors TCRs with two glycoproteins alpha and beta chain

128
Q

Are characterized by CD4, the coreceptor with the TCR for binding MHC class II molecules and the peptide it present, activated by such binding, helper T cells assist immune responses by producing cytokines that promote differentiation of B cells into the plasma cells, activate cytotoxic T lymphocytes and induce many parts of An inflammatory reactions

A

Helper T cells

129
Q

Are CD8, together with TCRs bind specific antigens on foreign cells or virus infected cells displayed by MHC class I molecules also result sin the population of memory cytotoxic T cells

A

Cytotoxic T lymphocytes

130
Q

In the presence of….., from helper T cells, cytotoxic T cells that have recognize such antigens are activated and proliferate

A

Interleukin 2

131
Q

Are CD4 CD25 and serve to inhibit specific immune responses, also identified by the presence of Foxp3 transcriptor factor

A

Regulatory T cells

132
Q

transcriptor factor crucial in allowing immune tolerance, mantaining unresponsiveness to self antigens and supressing excessive immune responses.

A

Foxp3

133
Q

Smaller subpopulation whose TCR contains gamma and delta chains , migrate to the epidermis and mucosal epithelia becoming largely intraepitelial and dont circulate in secundary lymphoid organs

A

Gamma- delta lymphocytes

134
Q

The retrovirus that produces…., infects and rapidly kills helper T cells, reduction of this lymphocytes group cripples the patient’s immune system rendering them susceptible to opportunistic bacterial, fungal, etc.

A

AIDS aquired immunodeficiency syndrome

135
Q

The surface receptors for antigens are monomers of IgM or IgD covered by about 150,000 such B cell receptors (BCR)

A

B lymphocytes

136
Q

BCR bind An antigen which may be free in solution, on An exposed part of An infectious agent, or already bound to antibodies and undergo

A

Endocytosis

137
Q

Degraded antigen in endosomes , peptides from the antigens are present on

A

MHC class II

138
Q

In all secundary lymphoid tissue B lymphocytes interact with

A

Follicular dendritic cells FDCs which have long filamentous processes are mesenchymal in origin

139
Q

Surface of follicular dendritic cells are covered with antibody-antigen complexes bound receptors for complement proteins and for immunoglobulin Fc regions causing B cells to attach and become activated and aggregate as a small

A

Primary lymphoid nodule or follicle

140
Q

With the help of adjacent Th cells, B cells form a much longer

A

Secondary lymphoid nodule

141
Q

Secondary nodules are characterized by a lightly stained ….. Filled with large Lymphoblast or centroblast undergoing immunoglobulin gene recombination, rapid proliferation and quality control

A

Germinal center

142
Q

Growth of activated B cells in germinal centers is exuberate and very rapid, causing noroliferating B cells to be pushed aside and produce

A

Mantle

143
Q

After ….. Weeks the germinal center and Mantle are dispersed

A

2 or 3 weeks

144
Q

Specific B lymphocytes differentiate into

A

Plasma cells secreting antibodies are said to provide humoral immunity

145
Q

Main function of thymus

A

Induction of central tolerance, which along regulatory T cells preventa autoimmunity

146
Q

Failure of the third (and fourth) pharyngeal pounches to develop normally in the embryo leads to

A

DiGeorge syndrome cause by thymic hypoplasia

147
Q

Each lobule has An outer darkly Basophilic

A

Cortex

148
Q

Cortex surround a more lightly stained

A

Medulla

149
Q

Three major types of thymic epithelial cells TECs

A

Blood thymus barrier
Cytorericulum
Corticomedullary barrier

150
Q

Squamous TECs form a layer joined by desmosomes and occluding junctions, line the connective tissue of the capsule and septa and surround the microvasculature, together with the vascular endothelial cells and pericytes forms

A

Blood thymus barrier

151
Q

TECs with processes containing keratin tonofilaments joined by desmosomes form a….., to which macrophages and lymphocytes attach instead of the reticulin fibers, express MHC both proteins, these cells are APCs

A

Cytoreticulum

152
Q

TECs that express MHC class II molecules but form a structure contribute in a barrier between the regions of each lobule

A

Corticomedullary barrier

153
Q

Three types of medullary TECs

A

A second layer of the boundary between cortex and medulla
A Cytoreticulum
Hassall corpuscles

154
Q

Up to 100 micrometers in diameter, secret cytokines that control activity of local dendritic cells, that promote development of regulatory T cells for peripheral tolerance

A

Hassall corpuscles

155
Q

The selection process for each pre T lymphocytes begin sin the cortex, ends in the medulla and last about

A

2 weeks

156
Q

Survival dependent on ability to bind to MHC molecule take place in the cortex in thymus

A

Positive selection

157
Q

Percentage of cells that undergo apoptosis because they dont bind to MHC molecule in positive selection

A

80%

158
Q

Occurs in medulla , survival dependent on not recognizing self antigen because medullary thymic epithelial cells express high level of Aire

A

Negative selection

159
Q

Percentage of cells survive selection Process in the thymus

A

2%

160
Q

Is one of the largest lymphoid organs containing up to 70% of all the body’s immune cells

A

MALT

161
Q

Most lymphocytes in MALT are

A

B cells

162
Q

Located posteriorly on the soft palade covered by stratified Squamous epithelium, the surface area is enlarged with 10 to 20 deep invagination or tonsillar crypt, is underlain by dense connective tissue that acts as partial capsule.

A

Palatine tonsils

163
Q

Situated along the base of the tongue covered by stratified squamous epithelium with cripts with lack distinct capsules

A

Lingual tonsils

164
Q

Situated in the posterior wall of nasopharynx covered by pseudostratified ciliated columnar epithelium with s thin underlain capsule, the mucosa is invaginated with shallow infolding but Lacks crypt

A

Pharyngeal tonsil

165
Q

Inflammation of tonsils, more common in children than adult

A

Tonsillitis

166
Q

Hyperplasia and enlargement of the tonsils to form

A

Adenoids

167
Q

Large aggregates of lymphoid nodules that contains dozens of nodules with no underlying connective tissue, located in ileum

A

Peyer patches

168
Q

The simple columnar epithelium that cover nodules of Peyer patches include large epithelial

A

M cells

169
Q

On the basal side M cells have

A

Large intracellular pockets with lymphocytes and dendritic cells and open to the underlying lymphoid tissue through a highly porous basement membrane

170
Q

A short, small diameter projection from the cecum, completely filled with lymphoid tissue, the lumen contains the normal flora of the large intestine and serve to retained beneficial bacteria ther during diarrheal ilnesses

A

Appendix

171
Q

Total present in the human body

A

400 - 450 lymph nodes

172
Q

Are bean shaped, encapsulated structures generally only 10 mm by 2.5 cm size

A

Lymph nodes

173
Q

Lymph nodes are more abundant in

A

Axillae (armpits) and groin, along the vessels of the neck, thorax, abdomen specially in mesenteries

174
Q

Valves in the lymphatic ensure the flow is

A

Unidorectional

175
Q

Three major regions of lymph nodes

A

Cortex
Medulla
Paracortex

176
Q

Cortex of lymph nodes includes

A

Subcapsular sinus

Lymphoid nodules

177
Q

Part of the lymph nodes Cortex immediately inside the capsule, receives lymph from afferent lymphatic. From this space cortical sinuses branch internally among the lymphoid nodules

A

Subcapsular sinus

178
Q

Part of the lymph nodes Cortex with or without germinal centers, fill most cortical áreas, formed largely by helper T lymphocytes and proliferating B Lymphoblast

A

Lymphoid nodules

179
Q

Region between the cortex and medulla does not have precise boundaries but can be distinguish from outer Cortex by its lack of B cells lymphoid nodules but contains T cells

A

Paracortex

180
Q

Specialized postcapillary venules in the paracortex , that represents An important entry point for most (90%) lymphocytes into lymph nodes, called

A

High endothelial venules HEVs

181
Q

Part of the lymph nodes medulla

A

Medullary cords

Medullary sinuses

182
Q

Part of the lymph nodes medulla are branched cordlike masses of lymphoid tissue extending from the paracortex that contain B and T lymphocytes and many plasma cells

A

Medullary cords

183
Q

Part of the lymph nodes medulla dilated spaces line by discontinuous endothelium that separate the medullary cords, are continuous with the cortical sinuses and converge at the hilium as the efferent lymphatic vessels

A

Medullary sinuses

184
Q

Neoplastic proliferation of lymphocytes producing a malignant

A

Lymphoma

185
Q

The largest single accumulation of lymphoid tissue in the body and the main site of old erythrocytes destruction

A

Spleen

186
Q

Percentage of white pulp of the spleen

A

20%

187
Q

Consist primarily of T cells with some macrophages ,DCs, and plasma cells as part of white pulp.

A

PALS

188
Q

Surround by PALS these vessels ar known as

A

Central arterioles

189
Q

Each central arteriol leaves the white pulp and enter the red pulp, losing its sheath of lymphocytes and branching as

A

Penicillar arterioles

HISTOLOGÍA (21 decks)

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