Thalassemia Vignette

Question 1

What is hemoglobin A2? And what proportion of hemoglobin will be found at birth and as an adult?

Answer 1

alpha2 delta 2; 1% at birth and 3.5% as an adult

Question 2

Hemoglobin C, another qualitative hemoglobinopathy, is a missense mutation in which _____ replaces ______, as opposed to valine in sickle-cell.

Answer 2

lysine; glutamate

Question 3

Cooley’s anemia is _______.

Answer 3

beta thalassemia major

Question 4

Beta thalassemia trait’s genotype is ______.

Answer 4

one normal gene and one missing or abnormal gene.

Question 5

Beta thalassemia intermedia’s genotype is ______.

Answer 5

two mildly abnormal genes

Question 6

Increasing alpha goblin production helps patients with Beta-Thalassemia major?

Answer 6

• False. !

- Increasing the other types of goblin would help, at least a little bit.