Lung Cancer Vignette

Question 1

Why does lung cancer have such a poor prognosis?

Answer 1

Late detection and lack of effective therapies for late-stage lung cancer

Question 2

Roughly ___ percent of lung cancers are detected at stage III and ___ percent at stage IV.

Answer 2

50; 35

Question 3

Screening high-risk patients (i.e., former or current smokers) has recently been shown to lead to a ____ percent reduction in mortality.

Answer 3

20

Question 4

What percent of lung cancers are small-cell and non-small-cell?

Answer 4

15% SC and 85% NSC

Question 5

The two cancers with FDA-approved specific drugs are _____ and _____.

Answer 5

ALK; EGFR

Question 6

____ is a monoclonal antibody that targets the PD1 receptor.

Answer 6

Nivolumab

Question 7

Crizotinib treats lung cancer with ____ mutations.

Answer 7

ALK+

Question 8

Avastin’s generic name is _______.

Answer 8

bevacizumab

Question 9

_______, whose brand name is Alimta, works by inhibiting three enzymes needed for purine and pyrimidine synthesis.

Answer 9

Pemetrexed

Question 10

Non-small cell lung cancer is now broken into ____ categories.

Answer 10

four

Question 11

____ is the most aggressive form of lung cancer.

Answer 11

Small cell lung cancer