Molecular Cytogenetics

Question 1

In acute lymphocytic leukemia (ALL), hyperploidy is indicative of a ____ prognosis.

Answer 1

good (aneuploidy with low chromosome count is an indicator of poor prognosis)

Question 2

What treatment is used for leukemias resulting from 15;17 PML/RARA translocation?

Answer 2

All trans retinoic acid (for acute promyelocytic leukemia APL)

Question 3

Those with Down syndrome have a 20-100x increased risk of ____ and a 500x increased risk of ____.

Answer 3

ALL/AML; AMKL (acute mega-karyoblastic leukemia)

Question 4

Chromosomal microarray can detect deletions or duplications that are greater than ____ base pairs long.

Answer 4

200 thousand (deletions) 400 thousand (duplications)

Question 5

Runs of homozygosity can indicate _____.

Answer 5

degree of consanguinity