Structural Chromosomal Abnormalities

Question 1

The three types of balanced translocations are _____.

Answer 1

Robertsonian, inversions, and reciprocal

Question 2

Which kind of segregation leads to normal chromosomes in meiosis of cells with translocations?

Answer 2

Alternate

Question 3

_____ segregation leads to trisomies or monosomies.

Answer 3

Adjacent 1

Question 4

What is the nomenclature designation for a karyotype that is trisomy 21 with one 21 connected to chromosome 14?

Answer 4

46, XX or XY, + 21 der(14;21) (q10; q10)

Question 5

______ inversions include the centromere.

Answer 5

Pericentric

Question 6

A person with inv(8) can have a child with ____ syndrome, whose features are ____.

Answer 6

recombinant 8 syndrome; hypertelorism, VSD, and thin upper lip

Question 7

The _____ blank population has a higher incidence of recombinant 8 syndrome, thought to be due to a founder’s effect.

Answer 7

Hispanic

Question 8

What type of cancer results from a reciprocal translocation?

Answer 8

Chronic Myelogenous Leukemia (9;22)