Receptor Tyrosine Kinase Flashcards
1
Q
What drives tyrosine phosphorylation?
A
Dimerization
2
Q
What serves as the GEF (guanosine exchange factor) for epidermal growth fact?
A
Grb2/SOS complex.
3
Q
What two proteins inactivate Ras?
A
Ras itself (constitutive GTPase activity) and GAP
4
Q
What does SH2 bind?
A
Phosphotyrosine-containing peptides
5
Q
What does SH3 bind?
A
Proline-containing peptides
6
Q
Which protein has a proline-rich region that binds to Grb2 SH3 domain?
A
SOS
7
Q
What protein has SH2 and SH3 domains?
A
Grb2
8
Q
What is the actual GEF for Ras?
A
Sos (bound to Grb2)
9
Q
Which phospholipase C is activated by tyrosine kinase receptors?
A
Phospholipase C gamma.
10
Q
Cetuximab binds to which part of the TKR?
A
The ligand-binding site
11
Q
Which drug inhibits the kinase activity of EGFRs and thus stops downstream signaling?
A
Gefitinib
