Pharmacogenetics

Question 1

Define pharmacogenetics.

Answer 1

The study of drug efficacy in response to variation in one allele.

Question 2

Define pharmacogenomics.

Answer 2

The study of drug efficacy in response t variation in multiple gene loci.

Question 3

What enzyme converts codeine to morphine?

Answer 3

CYP2D6. Having duplications of this will increase serum concentration.

Question 4

Pharmacokinetics is the ______ of drugs.

Answer 4

absorption, distribution, metabolism, and exctretion

Question 5

Pharmacodynamics describes the ________ of drugs.

Answer 5

concentration and effect

Question 6

Drugs are processed in two phases:

Answer 6

phase I is the addition of a hydroxyl group and phase II is the addition of chemical conjugates.

Question 7

_____ is given to treat acute lymphoblastic leukemia.

Answer 7

6-mercaptopurine

Question 8

Warfarin (coumadin) has a ____ intra-individual window and a ____ inter-individual window.

Answer 8

narrow; wide

Question 9

If azathioprine and 6MP are given to an ALL patient homozygous for ____, then they can undergo fatal _____.

Answer 9

TPMT (L); myelosuppression

Question 10

Those with G6PD mutations will have ____ if exposed to sulfa or dapsone.

Answer 10

hemolytic anemia

Question 11

Cyclosporine and ketoconazole are processed by ____, an enzyme that can be competitively inhibited by grapefruit juice.

Answer 11

CYP3A