Teratology (lecture)

Question 1

What is the most common cause of birth defects?

Answer 1

Meiotic abnormalities

Question 2

What are the three issues related with congenital rubella?

Answer 2

cataracts, deafniss, heart disease

Question 3

What enbyologic tissue is affected by valproic acid?

Answer 3

Neural tube

Question 4

What week of gestation is most susceptible to teratogens?

Answer 4

5th - no stage is safe though

Question 5

What is the most common result of teratogen exposure during the first two weeks of gestation?

Answer 5

Usually lethal

Question 6

What abnormalities are most common with teratogen exposure during weeks 6 and 7?

Answer 6

Facial

Question 7

Fetal sequelae related to CMV?

Answer 7

Microcephaly, blindness, mental retardation

Question 8

What fetal sequelae are related to HSV?

Answer 8

Microphthalmia, microcephaly, retinal dysplasia

Question 9

What fetal sequelae are associated with thalidomide?

Answer 9

Short limbs, mermaid, heart malformation

Question 10

Fetal sequelae of amphetamines?

Answer 10

Cleft lip / palate, heart defects

Question 11

Fetal sequelae of cocaine use by mom?

Answer 11

Growth retardation, microcephaly

Question 12

Fetal sequelae of lead exposure?

Answer 12

Growth retardation, neuro defects

Question 13

Fetal sequelae of retinoid acid exposure?

Answer 13

Brain, heart, ear, and thymus abnormalities

Question 14

What is NOT used to treat hyper cholesterolemia of pregnant women?

Answer 14

Statins

Question 15

What is the leading cause of mental retardation?

Answer 15

Alcohol use during pregnancy

Question 16

What is retinoic acid used to treat?

Answer 16

Acne

Question 17

What fetal sequelae are seen with steroid use?

Answer 17

genital tract abnormalities