Contraceptive (lecture)

Question 1

What is the MoA of IUD with and without progesterone ?

Answer 1

Both: Sterile inflammation –> PMNs destroy sperm

W. Prog.: also inhibits ovulation

Question 2

What is the primary MoA of depo provera?

Answer 2

Progesterone shot –> inhibit ovulation

Question 3

What is the MoA of OCPs?

Answer 3

Inhibit LH surge and ovulation

Estrogen component alters the glycogen production in endometrium

Question 4

What is the most reliable indication of menopause?

Answer 4

Increased FSH

Question 5

What is the MoA of emergency contraceptives?

Answer 5

altered tubal sperm transport

Disruption of corpus lute function

Question 6

What is the window of emergency contraceptive use and its limitation?

Answer 6

Must be taken within three days of coitus

It must be taken before ovulation

Question 7

What is the teratology risk of emergency contraceptives?

Answer 7

None

Question 8

What are the two strategies of male contraceptives?

Answer 8

1) Testosterone + progesterone to target the hypothalamus and pituitary for negative feedback
2) GnRH antagonists target pituitary