Drugs during pregnancy and breast feeding (lecture) Flashcards
What is the major deformation associated with thalidomide use during pregnancy?
Severe limb reduction
What gestational timeframe is most susceptible to limb defects?
4 - 8 weeks
What is meant by a drug that is category A?
Controlled studies in humans - no risk
What category would a drug that has been shown to have no teratogenic risks in animals, but no studies in humans have been conducted?
B
What category would a drug fall under if there have been no controlled studies (human nor animal) of teratology?
C
What drug class has been associated with Potter’s sequence?
Ace inhibitors: “-prils” and lorsartan
What category would a drug fall into if it has been shown to be associated with birth defect, but its benefits may outweigh its risks?
D
How would a drug be categorized if it was proven to be teratogenic, and the risks outweigh the possible benefits?
X
What are the defects associated with warfarin use during the first, second, and third trimesters?
First: Fetal warfarin syndrome
Second: Mental Retardation, Blindness
Third: Hemorrhage, Stillbirth
What deformation is associated with insulin use?
Caudal Regression
What is the most common preventable cause of mental retardation?
Alcohol use during pregnancy
Kid with absent philtrum, mid face hypoplasia, low nasal bridge, low set ears, microcephaly, shortened palpebral fissures. Dx?
Fetal alcohol syndrome
What malformations / complication are associated with: Cocaine LSD Marijuana Amphetamines Opioids
- Vascular
- None
- intrauterine Growth Restriction
- IUGR, cardiac, facial clefts
- Withdrawal
How is 17-OH-progesterone used during pregnancy?
Prevent preterm birth
How is oxytocin used during pregnancy?
Induce labor
