HIV (lecture) Flashcards
What HIV protein is responsible for initial binding?
gp120
What HIV protein is responsible for initial binding?
gp120
What HIV surface protein is responsible for fusion with target cell?
gp41
What cell types (3) are targeted by HIV?
CD4 T-cells, DC, Macrophage
What is the target cell co receptor targeted by HIV?
CCR5
What surface protein target switch in HIV is indicative of rapid progression?
From targeting CCR5 to CXCR4
What is the CD4 count that defines AIDS?
Where is the highest concentration of HIV in an uncircumscribed male?
Foreskin crypt
What are the two most common routes of vertical transmission of HIV?
Vaginal child birth
Breast feeding
During what time frame is the HIV viral load at its lowest?
12 - 60 months
How does acute HIV infection present?
Non specific symptoms: Lymphadenopathy and flu like
How is HIV diagnosed and the limitation of this test?
Western blot may be false negative for weeks post infection
What are the four targets of HIV treatment?
Entry inhibition
Reverse transcriptase inhibition
Integration inhibition
Protease inhibition
What HIV surface protein is responsible for fusion with target cell?
gp41
What cell types (3) are targeted by HIV?
CD4 T-cells, DC, Macrophage
