Teratogens Flashcards
ACEI
Renal damage
Alkylating agents
absence of digits
Aminoglycosides
Ototoxicity
Anti-epilectics
Neural tube
cardiac
cleft palate
skeletal (phalanx/nail hypoplasia, facial dysmorph.)
E.g. valproate, cabamazepine, phenytoin, phenobarbitol
High dose folate supp.
DES
Vaginal clear cell adenocarcinoma, Müllerian anomalies
Folate antagonists
Neural tube defects
Isotretinoin
Patients MUST be on contraception
Li
Ebstein anomaly
Methimazole
1st trimester; aplasia cutis
Tetracyclines
Discolored teeth, inhibited bones growth
Thalidomide
phocomelia
Warfarin
Bone deformities, fetal hemorrhage, abortion, eyes
EtOH
Birth defects, intellectual disability, FAS
Cocaine
Low birth weight, preterm birth, IUGR, placental abruption
Smoking
Low birth weight, preterm labor, placental problems, IUGR, SIDS
Iodine excess or deficiency
Cretinism
Maternal diabetes
Caudal regression syndrome (anal atresia to sirenomelia) Heart Neural tube Macrosmia Neonatal hypoglycemia
Methylmercury
Neurotox
Vit A excess
Spontaneous abortions, cleft palate, cardiac abnormalities
X-rays
Microcephaly, intellectual disability
