Important interleukins

Question 1

IL-1

Answer 1

Made by macrophages
Induces fever, acute inflammation, activates endothelium to express adhesion molecules, and induces WBC recruitment
Mediate sepsis

Question 2

Hot T-bone STEAK

Answer 2

IL-1- fever
2- T cells
3- bone marrow stim. 
4- IgE
5- IgA
6- aKute phase protein production

Question 3

IL-6

Answer 3

Made by macrophages
Fever, acute phase reaction proteins
Mediate sepsis

Question 4

IL-8

Answer 4

Made by macrophages

Chemotactic for neutrophils

Question 5

IL-12

Answer 5

Made by macrophages, induces Th1 diff.

Activate NKC

Question 6

TNF-alpha

Answer 6

Made by macrophages
Activates endothelium, WBC recruitment, NKC activation
Causes cachexia in malignancy, maintain TB granuloma,
Mediate sepsis

Question 7

IL-2

Answer 7

Made my all T cells

Activate Th, CTL, Treg and NKC

Question 8

IL-3

Answer 8

Made by all T cells
Growth and diff of BM cells
Like GM-CSF

Question 9

IFN-gamma

Answer 9

Made by Th1 and NKC in response to IL-12
Stims macrophages to kill phagocytosed pathogens
Inhib Th2 diff.

Question 10

IL-4

Answer 10

From Th2
Promotes Th2 differentiation
B-cell growth
IgE/G class switching

Question 11

IL-5

Answer 11

From Th2
B cell growth and differentiation
IgA class switching
Stim eos

Question 12

IL-10

Answer 12

Attenuates immune response
Made by Th2 and Treg
Decreases Th1 and MHCII expression
Inhibits macrophages and dendritic cells

Similar to TGF-beta