Acute phase reactants Flashcards
1
Q
Acute phase reactants
A
Increase in response to inflammation (acute or chronic)
Made in liver
Induced by IL-6
2
Q
C-reactive protein
A
Opsonin, fixes complement, facilitates phagocytosis
Non-spec. marker of inflammation
3
Q
Ferritin
A
Binds and sequesters iron to inhibit microbial scavenging
4
Q
Fibrinogen
A
Coag. factor, promotes endothelial repair, correlate with ESR
5
Q
Hepcidin
A
Lowers iron absorption (degrades ferroportin) and iron release from macrophages, anemia of chronic dz
6
Q
Serum amyloid A
A
Can lead to amyloidosis
7
Q
Albumin
A
DECREASED
Conserve AAs for positive reactants
8
Q
Transferrin
A
DECREASED
Internalized by macrophages to hide iron
