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Step Review Things to Memorize > Drug reactions > Flashcards

Drug reactions Flashcards

1
Q

Coronary vasospasm

A

amphetamines, cocaine, ergot alkaloids, sumatriptan

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2
Q

Cutaneous flushing

A

vancomycin, adenosine, niacin, nitrates, CCBs, echinocandins (-fungin)

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3
Q

DCM

A

Anthracyclines (doxorubicin, daunorubicin); prevent with dexrazoxane

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4
Q

Torsades de pointes

A

Class IA and III antiarrhythmics, antibiotics (macrolides), antipsychotics (haloperidol), antidepressants (TCAs) and antiemetics (ondansetron) ABCDE!

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5
Q

Adrenocortical insufficiency

A

glucocorticoid WITHDRAWL

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6
Q

Diabetes insipidus

A

lithium, demeclocycline

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7
Q

Hot flashes

A

tamoxifen, clomiphene

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8
Q

Hyperglycemia

A

Tacrolimus, protease inhibitors, niacin, HCTZ, corticosteroids

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9
Q

Hypothyroidism

A

Lithium, amiodarone, sulfonamides

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10
Q

SIADH

A

Carbamazepine, cyclophosphamide, SSRIs

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11
Q

Acute cholecystatic hepatitis, jaundice

A

Erythromycin

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12
Q

Diarrhea

A

Acamprosate, acarbose, cholinesterase inhibitors, colchicine, erythromycin, ezetimibe, metformin, misoprostol, orlistat, pramlintide, quinidine, SSRIs

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13
Q

focal to massive hepatic necrosis

A

Halothane, Amantia phalloides (death-cap mushroom), valproic acid, acetominophen

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14
Q

Hepatits

A

Rifampin, isoniazid, pyrazinamide, statins, fibrates

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15
Q

Pancreatitis

A

Didanosine, corticosteroids, alcohol, valproic acid, azothioprine, furosemide, HCTZ

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16
Q

Pill esophagitis

A

bisphosphonates, ferrous sulfate, NSAIDs, KCl, tetracyclines

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17
Q

Pseudomembranous colitis

A

Ampicillin, cephalosporins, clindamycin, fluoroquinolones (leads to C. difficile)

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18
Q

Agranulocytosis

A

Clozapine, carbamazepine, PTU, methimazole, colchicine, ganciclovir

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19
Q

Aplastic anemia

A

Carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, PTU

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20
Q

Direct Coombs+ hemolytic anemia

A

Methyldopa, penicillin

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21
Q

Drug reaction with eosinophilia and systemic symptoms (DRESS)

A

Allopurinol, anticonvulsants, antibiotics, sulfa drugs

Potentially fatal, latency 2-8wk; tx: GC

22
Q

Gray baby syndrome

A

Chloramphenicol

23
Q

Hemolysis in G6PDH deficiency

A

Isoniazid, sulfonamide, dapsone, primaquine, asprin, ibuprofen, nitrofurantoin

24
Q

Megaloblastic anemia

A

Hydroxyurea, phenytoin, MTX, Sulfadrugs

25
Q

Thrombocytopenia

A

Heparin

26
Q

Thromboses

A

E+P contraceptives, HRT, SERMs (tamoxifen, raloxifene, clomiphene) MEDIATED BY ESTROGEN

27
Q

Fat redistribution

A

Protease inhibitors, GCs

28
Q

Gingival hyperplasia

A

Phenytoic, CCBs, cyclosporin

29
Q

Hyperuricemia

A

Pyrazinamide, thiazides, furosemide, niacin, cyclosporine

30
Q

Myopathy

A

statins, fibrates, niacin, colchicine, daptomycin, hydroxychloroquine, IFN-alpha, penicillamine, GCs

31
Q

Osteoporosis

A

CS, depot medroxyprogesterone acetate, GnRH agonists, aromatase inhibitors, anticonvulsants, heparin

32
Q

Photosensitivity

A

Sulfonamides, amiodarone, tetracyclines, 5-FU

33
Q

Rash (Stevens-Johnson)

A

Anti-epileptics (esp. lamotrigine), allopurinol, sulfa drugs, penicillin

34
Q

Teeth discoloration

A

tetracycline

35
Q

Tendonitis, tendon rupture, cartilage damage

A

fluoroquinolones

36
Q

Cinchonism (tinnitus, hearing/vision loss, psychosis, cognitive impariment

A

Quinidine, quinine

37
Q

Parkinson-like syndrome

A

Antipsychotics, reserpine, metoclopramide

38
Q

Seizures

A

INH (B6 deficiency), buproprion, imipenem/cilastin, tramodol, enflurane

39
Q

Tardive dyskinesia

A

Antipsychotics, metoclopramide

40
Q

Fanconi syndrome

A

Cisplatin, ifosfamide, expired tetracyclines, tenofovir

41
Q

Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide

Give with mesna

42
Q

Interstitial nephritis

A

Penicillins, furosemide, NSAIDs, PPIs, sulfa drugs

43
Q

Dry cough

A

ACEIs

44
Q

Pulmonary fibrosis

A

MTX, nitrofurantoin, carmustine, bleomycin, busulfan, amiodarone

45
Q

Antimuscarinic

A

Atropine, TCAs, H1-blockers, antipsychotics

46
Q

Disulfiram-like reaction

A

1st gen. sulfonuryeals (-mide), procarbazine, cephalosporins, griseofulvin, metronidazole

47
Q

Nephrotox/ototox

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin, amphotericin B

48
Q

CYP inducers

A 
Chronic EtOH
St John's wort
Phenytoin
Phenobarbital
Nevirapine
Rifampin
Griseofulvin
Carbamazepine
49
Q

CYP substrates

A

Anti-epileptics
Theophylline
Warfarin
OCP

50
Q

CYP Inhibitors

A 
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Acute Alcohol Abuse
Chloramphenicol
Macrolides
Sulfonamides
Ciprofloxacin
Omeprazole
Metronizadole
51
Q

Sulfa drugs

A

Sulfonamide antibiotics, sulfasalazine, probenecid, furosemide, acetazolamide, celecoxib, thiazides, solfonylureas

Fever, UTI, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, AIN, urticaria

Mild to life-threatening

Step Review Things to Memorize (41 decks)

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