Oncogenes (gain of function) Flashcards by Robert Gaffey | Brainscape

Q

ALK

A

Receptor tyrosine kinase

Lung adenocarcinoma

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Q

BCR-ABL

A

Tyrosine kinase

CML, ALL

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Q

BCL-2

A

Anti-apoptosis

Follicular and DLBC lymphomas

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Q

BRAF

A

Serine/threonine kinase

Melanoma, NHL, papillary thyroid carcinoma

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Q

c-KIT

A

Cytosine receptor

GIST

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Q

c-MYC

A

Transcription factor

Burkitt lymphoma

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Q

HER2/neu (c-erbB2)

A

Receptor tyrosine kinase

Breast and gastric carcinoma

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Q

JAK2

A

Tyrosine kinase

Chronic myeloproliferative disorders

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Q

KRAS

A

GTP kinase

Colon, lung and pancreatic cancers

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Q

MYCL1

A

Transcription factor

Lung tumor

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Q

MYCN

A

Neuroblastoma

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Q

RET

A

Receptor tyrosine kinase

MEN2A/B, medullary thyroid cancer

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