Serum tumor markers Flashcards
1
Q
Alkaline phosphatase
A
Mets. to bone or liver, Paget disease of bone, seminoma (placental ALP)
R/O hepatic by checking LFTs and GGT
2
Q
alpha-fetoprotein
A
HCC, hepatoblastoma, yolk sac tumor, mixed germ cell tumor
Transiently elevated in normal pregnancy
High level- neural tube/abd. wall defects
Low level- Down syndrome
3
Q
beta-hCG
A
Hydatidiform moles and choriocarcinomas (gestational trophoblastic disease), testicular cancer, mixed germ cell tumor
Made by syncitiotrophoblasts of placenta
4
Q
CA 15-3/CA 27-29
A
Breast cancer
5
Q
CA 19-9
A
Pancreatic andenocarcinoma
6
Q
CA 125
A
Ovarian cancer
7
Q
Calcitonin
A
Medullary thyroid carcinoma (including MEN2A/B)
8
Q
CEA
A
CRC and pancreatic Carcinoembryonic antigen (non-specific)
9
Q
Chromogranin
A
Neuroendocrine tumors
10
Q
PSA
A
Prostate ca.
Also up in BPH and prostatitis\
Surveillance post-prostatectomy
