Helper T-cell differentiation

Question 1

Th1

Answer 1

Promoted by: IL-12, IFN-gamma
Down-reg. by: IL-4, IL-10 (from Th2)
Make: IFN-g and IL2
Target: Macrophages and CTLs
Defend against: Intracellular pathogens
Role in: Autoimmunity, chronic inflammation

Question 2

Th2

Answer 2

Promoted by: IL-2, IL-4
Down-reg. by: IFN-gamma (Th1)
Make: IL-4, IL-5, IL-6, IL-10, IL-13
Target: Eos and promote B-cell IgE production
Defend against: helminths
Role in: Allergy

Question 3

Th17

Answer 3

Promoted by: TGF-beta, IL-6
Down-reg. by: 
Target: Neutrophils
Defend against: Extracellular pathogens
Role in: Autoimmunity

Question 4

Treg

Answer 4

Upregulated by TGF-beta
Express: CD3/4/25/FOXP3
Secrete IL-10 and TGF-beta
Calm down immune system