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Clinical Pathology (RIP) > T8 - L2 CMPD and CML > Flashcards

T8 - L2 CMPD and CML Flashcards

1
Q

what are chronic myeloproliferative disorders?

A
  • Clonal stem cell disorders of the bone marrow

- malignant

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2
Q

list some chronic myeloproliferative disorders?

A
  1. Polycythaemia Vera (PV)
  2. Essential thrombocytosis (ET)
  3. Idiopathic Myelofibrosis (IMF)
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3
Q

what are symptoms of Polycythaemia Vera (PV)?

A
  • Insidious
  • Itching (aquagenic- hot baths)
  • Plethoric face
  • Headache, muzziness,
  • General malaise
  • Tinnitus
  • Peptic ulcer
  • Gangrene of the toes
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4
Q

what are signs of Polycythaemia Vera (PV)?

A
  • Plethora
  • Engorged retinal veins
  • Splenomegaly
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5
Q

The presence of a JAK2 V617F mutation

in peripheral blood DNA is diagnostic of what?

A

myeloproliferative disorder

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Clinical Pathology (RIP) (49 decks)

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