T4 - L5 MHC and transplant rejection

Question 1

what does allogeneic mean?

Answer 1

tissues or cells which are genetically dissimilar and hence immunologically incompatible

Question 2

what is Major Histocompatibilty Complex (MHC)?

Answer 2

cell surface proteins required for the immune system to recognise foreign/self molecules

Question 3

what is “second set rejection”

Answer 3

e.g.

If a second skin graft is done on the same patient with the same skin graft, it is called the
“second set” rejection

• gets rejected much quicker → Proving memory response

Question 4

what is HLA?

Answer 4

human leukocyte antigen (HLA)

Question 5

what is the difference between MHC and HLA?

Answer 5

MHC found in all vertebrae

HLA only found in humans

HLA is a type of MHC

Question 6

on which cells will you find MHC class I?

Answer 6

Found on all nucleated cells

so not found on RBCs

Question 7

on which cells will you find MHC class II?

Answer 7

specialised APC

Question 8

what type of MHC would you find on a SMC?

Answer 8

MHC class I

Question 9

what type of MHC would you find on a macrophage?

Answer 9

MHC class II

Question 10

what type of MHC would you find on a dendritic cell?

Answer 10

MHC class II

Question 11

what is the function of the MHC?

Answer 11

present antigens (self or foreign) to T cells