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FISIOPATO > T7. RI > Flashcards

T7. RI Flashcards

1
Q

133

A
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2
Q

DEFINICAO

A
  • resposta biologica e fisiológica dos tecidos vivos a agressao fundamentada na vascularizacao e que conduz a orientacao dos meios de resposta para o local onde se processou a agressao
  • cels si e mediadores
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3
Q

ETIOLOGIA

A

infecao, queimadora, autoimune, HTA, cancro, isquemia…

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4
Q

sinais cardinais

A

rubor dor calor tumor
(cornelius celsus)

impotencia funcional
(rudolph virchow)

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5
Q

mecanismos

A

ver slide 138

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6
Q

fagocitose

A

slide 139

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7
Q

mediadores celulares

A

etapas na circulacao

  • rolling (selectinas)
  • ativacao
  • aderencia (CD 1 e 18 E ICAM)
  • transmigracao (PECAM I)

mediadores

  • PMN na circulacao aumentam 10x na inflamacao aguda
  • monocitos nos tecidos viram macrofagos
  • eosinofilos vao p circulacao e ficam varios dias nos tecidos
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8
Q

sistema fagocitico mononucleado

A
  • monocitos na circulacao

macrofagos

  • kupfer (figado)
  • messangial (rim)
  • microglia (snc)
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9
Q

mastocitos

A

Ativacao
igE, complemento, mo…

desgranulacao
hsitamina, leucotrienos, prostaglandinas…

leva a

  • quimiotaxia
  • recrutamento seletivo cels efetoras
  • expressao moleculas de adesao
  • permeabilidade vascular
  • prod peptidos antimicrobianos

consequencia

  • rinite, urticaria, asma
  • mastocitose
  • …
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10
Q

cels endoteliais

A

superficie nao aderente, prevenindo coagulacao, aderencia celular e saida de liquidos

componetntes vasodilatadores

  • NO
  • prostaciclina

componentes vasoconstritores

  • endotelina
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11
Q

mediadores soluveis

A

slide 145

il1.6 e TNF mt ligados a resposta fase aguda

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12
Q

complemento

A
  • 9 ptn principais

lise celular

  • c5-9 e MAC

opsonizacao

  • c3b e 4b

clearance de imunocomplexos

  • c3b

ri

  • c3a, c4a, c5a (anafilatoxinas) induzem reposta imune
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13
Q

proteinas ri e pcr

A

slide 148 e p4

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14
Q

resposta de fase aguda

A
  • alt em 25% concentracao proteinas plasmaticas no processo inflamatorio

alteracoes

  • neuroendocrinas
  • hepaticas
  • metabolicas
  • hematopoieticas
  • constituintes plasmaticos
    (fe, zn e cobre)
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15
Q

inflamacao boa e ma

A

boa- AGUDA

  • primeira definicao da aula

ma- CRONICA

  • inflamacao prolongada no tempo onde pode ocorrer em simultaneo inflamacao ativa, lesao tecidular e cicatrizacao
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16
Q

RI envelhecimento

A

slide 154

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