T3 - Non-Hodgkins Lymphoma, Aplastic Anemia, Retinoblastoma Flashcards
Non-Hodgkins Lymphoma derives from which type of cells?
Mature B Cells
T Cellls
Cells of uncertain lineage
What are the three most common malignancies in children?
Acute Leukemia
Brain Tumor
Non-Hodgkins Lymphoma
What are the most common sites for NHL?
Abdomen
Mediastinum
Head/Neck
What s/s of NHL in abdomen?
pain
distention
n/v
S/S of NHL in Mediastinum?
pleural effusion
pain
dyspnea
dysphagia
SVC syndome (sweating of upper arm, face, and neck)
S/S of NHL in Head/Neck
painless, non-tender mass
Which treatment is used the most w/ NHL?
Chemo
- occasionally radiation if tumor interferes w/ vital structures
- occasionally surgery where debulking is beneficial
What is the most important factor in determining prognosis of NHL?
extent of disease at Dx is determined by pretreatment staging
Clinical manifestations of NHL
Lymph node involvement in limitation to 1 or 2 adjacent lymphatic regions
Extra nodal site, nasopharynx, oropharynx, or other isolated extra nodular sites with or without lymphadenopathy
GI involvement limited to mesentery
— is a tumor of the eye.
Retinoblastoma
80% of Retinoblastomas are diagnosed at what age?
before age 5
What is noteworthy about the genetics of Retinoblastoma?
gene is present in all body cells in inherited from but only tumor cells in non-inherited form
S/S of Retinoblastoma
FTT
Strabismus
Glaucoma
Orbital Cellulitis
Blood Shot Eyes
Nystagmus
Leucocoria (white discoloration of pupil)
What does fundus examination reveal?
allows visualization of the entire retina in both eyes to determine extent of tumor
What is the most important factor in the prognosis for visual acuity w/ Retinoblastoma?
early diagnosis
