systemic sclerosis Flashcards
what
autoimmune inflammatory and fibrotic connective tissue disease
limited cutaneous systemic sclerosis
more limited version
limited cutaneous systemic sclerosis - features
Calcinosis Raynaud's Esophageal dysmobility Screlodactyly Telangiectasia
diffuse cutaneous systemic sclerosis - features
CREST CVD - htn, CAD pulm htn pulm fibrosis GN scleroderma renal crisis
scleroderma
hardening of skin
shiny tight skin w/o normal folds
sclerodactyly
skin changes in hands
restuct ROM
skin can break and uclerate
calcinosis
calcium deposits build up under skin
most commonly found on fingertips
scleroderma renal crisis
acute condition where there is combination of severe htn + renal failure
Autoantibodies
ANA
Anti-centromere antibodies - limited cuteneous
anti-Scl-70 - diffuse cutaneous - more severe disease
nailfold capillaroscopy
measure health of peripheral capillaries
abnormal capillaries, avascular areas + micro-haemorrhages indicate systemic sclerosis
Mx - non medical
stop smoking skin stretching to maintain ROM emolients physiotherapy OT
Mx - medical
nifidepine - Raynayds PPI and metoclopramide analgesia antibx ACEI
