SLE Flashcards
1
Q
more common in …
A
women
asians
2
Q
when does it usually present
A
young-middle aged aduls
3
Q
often takes a X course
A
relapsing remitting
flare up and periods where symptoms improced
4
Q
pathophysiology
A
ANA antibodies to proteins within cells nucleus
immune system targets these proteins and causes inflammatory response
5
Q
presentation
A
fatigue weight loss arthralgia + myalgia fever photosensitive malar rash lymphadenopathy splenomegaly SOB pleuritic chest pain mouth ulcers hair loss raynaud's
6
Q
Ix
A
autoantibodies FBC CRP and ESR Ig urinarlysis renal biopsy
7
Q
FBC shows
A
normocytic anaemia of chronic disease
8
Q
autoantibodies
A
anti-nuclear antibodies
anti-double stranded DNA (anti-dsDNA)
9
Q
types of ANA
A
anti-smith anti-centromere anit-ro and anti La anti-scl-70 anti-jo-1
10
Q
diagnosis
A
SCLICC or ACR criteria
11
Q
complications
A
CVD infection anaemia of chronic disease pericarditis pleuriris ILD lupus nephritis optic neuritis, transverse myelitis recurrent misscarriage VTE if antiphosholipid syndrome
12
Q
first line treatments
A
NSAID
steroids - prednisolone
hydroxychloroquine (1st for mild SLE)
suncream and sun avoidance
13
Q
commonly used immunosuppresents in resistant/more severe SLE
A
methotrexate mycophenolate mofetil azathioprine tacrolimus ciclosporin leflunomide
14
Q
Mx severe/resistant
A
biologic therapoes
rituximab
belimunab
15
Q
rituximab
A
cd20 monoclonal antibody
