antiphospholipid syndrome

Question 1

what

Answer 1

disorder assoc w antiphospholipid antibodies where blood becomes prone to clotting

hyper-coaguable state

Question 2

antiphospholipid antibodies

Answer 2

lupus anticoagulant
anticardiolipin antibodies
anti-beta 2 glycoprotein I antibodies

Question 3

clinical features

Answer 3

VTE
arterial thrombosis
pregnancy complications
livedo reticularis
libmann-Sacks endocarditis
thrombocytopenia

Question 4

associations - VTE

Answer 4

DVT

PE

Question 5

associations - arterial thrombosis

Answer 5

stroke
MI
renal thrombosis

Question 6

associations - pregnancy complications

Answer 6

recurrent misscarriage
stillbirth
PET

Question 7

associations - livedo reticularis

Answer 7

purple lace like rash

gives mottled appearance to skin

Question 8

associations - libmann sacks endocarditis

Answer 8

type of non-bacterial endocarditis

growths (vegeations) on heart valves

Question 9

diagnosisi

Answer 9

Hx thrombosis
Hx pregnancy complications
persistent antibodies

Question 10

Mx - non-pregnant

Answer 10

longterm warfarin with INR range 2-3 to prevent thrombosis

Question 11

Mx - pregnant

Answer 11

LMWH (enoxaparin) plus aspirin

warfarin is contraindicated in pregnancy