paget's disease Flashcards
1
Q
what
A
excessive bone turnover
excess acvtivity of both osteoclasts and osteoblasts
2
Q
results in
A
patchy areas of high density (sclerosis) and low density (lysis)
- -> enlarged and misshapen bones
- -> inc risk pathological #
3
Q
presentation
A
bone pain
bone deformity
fractures
hearing loss if affects bones of ear
4
Q
typically affects
A
older adults
5
Q
xray findings
A
osteoporosis circumscripta
cotton wool appearance
v shaped defects
6
Q
biochemistry findins
A
raised alkaline phosphatase
normal calcium
normal phosphate
7
Q
Mx - mainstay of trreatment
A
bisphosphonates
8
Q
Mx - other measures
A
NSAIDs
calcium and VitD supplements
9
Q
monitoring invovled
A
check serum ALP and review symptoms
effective treatment should normalise ALP
10
Q
two key complications
A
osteogenic sarcoma (osteosarcoma)
spinal stenosis + spinal cord compression
