osteoporosis Flashcards

1
Q

what

A

reduction in bone density

= bone less strong and more prone to #

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2
Q

osteopenia

A

less severe reduction in bone density

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3
Q

risk factors

A
older age 
female 
reduced mobility 
low BMI 
alcohol and smoking 
RA
long term corticosteroids
SSRIs, PPIs, anti-oestrogens
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4
Q

key group to consider osteoporosis in

A

post-menopausal women

oestrogen is protective against osteoporosis and unless theyre on HRT they have less oestrogen

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5
Q

FRAX tool

A

gives risk of fragility fracture over next 10 years

gives results as percentage of 10yrs probabiloty of a

  • major osteoporotic fracture
  • hip fracture
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6
Q

bone mineral density

A

measured using DEXA scan

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7
Q

DEXA scan

A

dual-energy xray absorptiometry

measure how much radiation is absorbed by bones ie how dense they are

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8
Q

bone mineral density: Z score

A

represents no. of standard deviations the pt BMD falls below mean for their age

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9
Q

bone mineral density: T score

A

No. of standard deviations below mean for healthy young adult their BMD is

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10
Q

bone mineral density: most important clinical outcome

A

T score of persons hip

basis for WHO classification of level of osteoporosis

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11
Q

WHO classification T score at hip: > -1

A

BMD is normal

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12
Q

WHO classification T score at hip: -1 to -2.5

A

osteopenia

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13
Q

WHO classification T score at hip: < -2.5

A

osteoporosis

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14
Q

WHO classification T score at hip: < -2.5 plus a fracture

A

severe osteoporosis

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15
Q

first step in assessing osteoporosis

A

FRAX assessment

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16
Q

who to do FRAX assessment on

A

women >65
men >75
younger pt w risk factors: Hx fragility #, Hx falls, low BMI< longterm steroids, endocrine disorders, RA

17
Q

FRAX outcomes if calculates without BMD

A

low risk = reassure
intermediate risk = offer DEXA scan and recalcuate SCAN with BMD result
high risk = Rx

18
Q

FRAX outcomes with BMD

A

treat

lifestyle advice + reassure

19
Q

Mx - lifestyle changes

A
activity 
maintian healthy weight
adequate calcium 
adequate vitamin D
avoid falls 
stop smoking 
reduce alcohol
20
Q

Mx - VitD and Calcium

A

calcium supplementation with VitD if risk fragilty# and inadequate calcium

e.g. Calcichew-D3

21
Q

1st line treatment for osteoporosis

A

bisphosphonates

22
Q

bisphosphonates S/Es

A

reflux + oesophageal erosions
atypical fractures
osteonecrosis jaw
osteonecrosis external auditory canal

23
Q

denosumab

A

monoloncal antibody against osteoclasts

24
Q

follow up of patients on bisphosphonates

A

repeat FRAX and DEXA scan after 3-5yrs

consider treatment holiday if BMD has improved and have not had a fragility #