behçets disease

Question 1

what

Answer 1

complex inflammatory condition

characteristically presenting with recurrent oral and genital ulers

Question 2

link with what gene

Answer 2

HLA B51

Question 3

prognostic indicator of severe disease

Answer 3

HLA B51

Question 4

features: mouth ulcera

Answer 4

3 episodes per year

painful, circumscribes w red halo

heal over 2-4wks

Question 5

features: genital ulcers

Answer 5

kissing ulcers

Question 6

features: skin

Answer 6

erythema nodosum
papules + pustules
vasculitic type rashes

Question 7

features: eyes

Answer 7

anterior or posterior uveitis
retinal vasculitis
retinal haemorrhage

Question 8

features: MSK

Answer 8

AM stiffness
arthralgia
oligoarthritis usually knee or ankle

Question 9

features: GI

Answer 9

inflammation affecting

• ileum
• caecum
• asc colon

Question 10

features: CNA

Answer 10

memory impairment
headache
aseptic meningitis
meningoencephalitis

Question 11

features: veins

Answer 11

budd chiari syndrome
DVT
thrombus in pulmonary veins
cerebral venous sinus thrombosis

Question 12

features: lungs

Answer 12

pulmonary artery aneurysms can develop

if rupture can be fatal

Question 13

diagnosis based on

Answer 13

clinicla features

Ix = pathergy test

Question 14

pathergy test

Answer 14

sterile needle to create s/c abrasion on forearm

review it 24-48hrs after to look for a weal 5mm or more

tests for non-specific hypersensitivity of skin

Question 15

when can pathergy test be positive

Answer 15

behcet’s disease
sweets syndrome
pyoderma gangrenosum

Question 16

Mx

Answer 16

topical and systemic steroids
colchicine
topical anaesthetics
immunosuppresion 
biologics

Question 17

prognosis

Answer 17

relapsing remitting condition

normal life expectancy and can go into remission

inc mortality with haemoptysis, neurolgical involvement