Synaptic Transmission Drugs (general)

Question 1

Metyrosine

Answer 1

Indication: Hypertension

MoA: Competitive inhibition of tyrosine hydroxylase

Question 2

Reserpine

Answer 2

Indication: Hypertension

MoA: Inhibits VMAT uptake of monoamines

Question 3

Bretylium

Answer 3

Indication: Ventricular Arrhythmia

MoA: Inhibit action potential generation and calcium dependent synaptic vesicle fusion

Question 4

Cocaine

Answer 4

Indication: Analgesia in surgery

MoA: Blocks monoamine reuptake

Question 5

Amphetamine or ephedrine

Answer 5

Indication: Narcolepsy, ADHD

MoA: Reverse monamine reuptake transporters

Question 6

Naloxone, naltrexone

Answer 6

Indication: Opioid overdose or dependence

MoA: Non-peptide blockers of opioid receptors in CNS

Question 7

SSRIs

Answer 7

Indication: Depression/anxiety

MoA: Selective inhibition of serotonin reuptake transporter

Question 8

ACE inhibitors (lisinopril)

Answer 8

Indication: Hypertension

MoA: Inhibits peptide cleavage of angiotensin I to angiotensin II

Question 9

Phenylephrine

Answer 9

Indication: Hypotension during surgery

MoA: Direct agonist of adrenergic receptor

Question 10

MAO inhibitors

Answer 10

Indication: Depression

MoA: Blockade of cytoplasmic metabolism of monoamines

Question 11

L-DOPA

Answer 11

Indication: Parkinson’s disease

MoA: Precursor of dopamine, stimulate dopamine production

Question 12

Carbidopa

Answer 12

Indication: Parkinson’s disease

MoA: Blocks L-Dopa conversion to dopamine, does not cross BBB so protect peripheral adrenergic neurons from producing too much dopamine and norepinephrine

Question 13

Tyramine

Answer 13

Indication: Ingested in diet, not therapeutic

MoA: Competes with NE for transpsort into synaptic vesicle