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Psych Drugs Flashcards

1
Q

Lithium

A

Anticonvulsant aka mood stabilizer

Bipolar Drug

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2
Q

Carbamazepine (Tegretol)

A

Anticonvulsant aka mood stabilizer
Bipolar Drug

No bipolar depression

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3
Q

Valproic Acid (Depakene and Depakote)

A

Anticonvulsant aka mood stabilizer
Bipolar Drug

No bipolar depression

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4
Q

Lamotrigine (Lamictal)

A

Anticonvulsant aka mood stabilizer
Bipolar Drug

No acute mania

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5
Q

Haloperidol (Haldol)

A

First Generation Antipsychotic
Butyrophenone
Bipolar Drug

High potency

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6
Q

Chlorpromazine (Thorazine)

A

First Generation Antipsychotic
Phenothiazine
Bipolar Drug

Low potency
First antipsychotic discovered

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7
Q

Risperidone (Risperdal)

A

Second Generation Antipsychotic

Bipolar Drug

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8
Q

Paliperidone (Invega)

A

Second Generation Antipsychotic

Bipolar Drug

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9
Q

Geodone (Ziprasidone)

A

Second Generation Antipsychotic
Bipolar Drug

No bipolar depression
QTc prolongation!

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10
Q

Iloperidone (Fanapt)

A

Second Generation Antipsychotic

Bipolar Drug

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11
Q

Lurasidone (Latuda)

A

Second Generation Antipsychotic

Bipolar Drug

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12
Q

Clozapine (Clozaril)

A

Second Generation Antipsychotic

Bipolar Drug

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13
Q

Olanzapine (Zyprexa)

A

Second Generation Antipsychotic

Bipolar Drug

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14
Q

Olanzapine + Fluoxetine (Symbyax)

A

Second Generation Antipsychotic + SSRI

Bipolar Drug

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15
Q

Quetiapine (Seroquel)

A

Second Generation Antipsychotic

Bipolar Drug

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16
Q

Asenapine (Saphris)

A

Second Generation Antipsychotic

Bipolar Drug

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17
Q

Aripiprazole (Abilify)

A

Second Generation Antipsychotic
Partial agonist
Bipolar Drug

No bipolar depression

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18
Q

Imipramine (Tofranil)

A

TCA
Tertiary

Long acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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19
Q

Amitriptyline (Elavil)

A

TCA
Tertiary

Long acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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20
Q

Desipramine (Norpramin)

A

TCA

Secondary

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21
Q

Nortriptyline (Pamelor)

A

TCA

Secondary

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22
Q

Clomipramine (Anafranil)

A

TCA

3 but act like 2

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23
Q

Doxepin (Sinequan)

A

TCA
3 but act like 2

Long acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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24
Q

Fluoxetine (Prozac)

A

SSRI

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25
Paroxetine (Paxil)
SSRI
26
Sertraline (Zoloft)
SSRI
27
Fluvoxamine (Luvox)
SSRI
28
Citalopram (Celexa)
SSRI
29
Escitalopram (Lexapro)
SSRI
30
Duloxetine (Cymbalta)
SNRI
31
Venlafaxine (Effexor)
SNRI
32
Desvenlafaxine (Pristiq)
SNRI Metabolite of Venlafaxine
33
Bupropion (Wellbutrin, Zyban)
Atypical Antidepressant NE and DA reuptake inhibition Welbutrin is antidepressant Zyban reduces craving for nicotine
34
Mirtazapine (Remeron)
Atypical Antidepressant a2 adrenergic receptor antagonist (increases NE and 5-HT) Long acting Anti-histaminergic action (aka sedation SE) used for sleep disorder
35
Nefazodone (Serzone)
Atypical Antidepressant 5-HT2A antagonist and 5-HT reuptake inhibitor Intermediate acting Anti-histaminergic action (aka sedation SE) used for sleep disorder
36
Trazodone (Deseryl)
Atypical Antidepressant Blocks 5-HT2 and a1-adrenergic receptors Intermediate acting Anti-histaminergic action (aka sedation SE) used for sleep disorder
37
Vilazodone (Viibryd)
Atypical Antidepressant | 5-HT reuptake inhibitor and 5-HT1A partial agonist
38
Vortioxetine (Brintellix)
Atypical Antidepressant | 5-HT reuptake inhibition and 5-HT1A full agonist
39
Tranylcypromine
MAOI
40
Phenelzine
MAOI
41
Isocarboxazid
MAOI
42
Selegiline
MAOI (selective B)
43
Moclobemide
Reversible MAOI
44
Chlordiazepoxide (Librium)
Benzodiazepine Long t1/2 Long acting Metabolite is desmethyldiazepam
45
Diazepam (Valium)
Benzodiazepine Long t1/2 Long acting Metabolite is desmethyldiazepam
46
Flurazepam
Benzodiazepine Long t1/2 Long acting Approved for insomnia
47
Flunitrazepam (Rohypnol)
Benzodiazepine Long t1/2 aka Date Rape drug
48
Clonazepam (Klonopin)
Benzodiazepine Long t1/2
49
Midazolam (Versed)
Benzodiazepine Moderate t1/2 Short acting
50
Alprazolam (Xanax)
Benzodiazepine Moderate t1/2 Intermediate acting
51
Triazolam (Halcion)
Benzodiazepine Moderate t1/2 Short acting Approved for insomnia, high abuse potential
52
Lorazepam (Ativan)
Benzodiazepine Short t1/2 Intermediate acting Phase II only! Not FDA approved for insomnia but commonly prescribed for it
53
Oxazepam (Serax)
Benzodiazepine Short t1/2 Intermediate acting Phase II only!
54
Temazepam (Restoril)
Benzodiazepine Short t1/2 Phase II only! Approved for insomnia
55
Estazolam (ProSom)
Benzodiazepine Intermediate acting Approved for insomnia
56
Chlorazepate (Tranxene)
Benzodiazepine Long t1/2 Long acting Metabolite is desmethyldiazepam
57
Zolpidem (Ambien)
Selective Non-Benzodiazepine Imidazopyridine Short acting
58
Zaleplon (Sonata)
Selective Non-Benzodiazepine Imidazopyridine Short acting
59
Eszopiclone (Lunesta)
Selective Non-Benzodiazepine Pyrrolopyrazine Short acting
60
Phenobarbital (Luminol Sodium)
Barbiturate Long t1/2 Long acting
61
Methohexital
Barbiturate
62
Thiopental
Barbiturate Short t1/2 Short acting
63
Mexihexital
Barbiturate Short t1/2
64
Amobarbital (Amytal)
Barbiturate Moderate t1/2
65
Secobarbital (Seconal)
Barbiturate Moderate t1/2
66
Pentobarbital (Nembutal)
Barbiturate Moderate t1/2 Long acting
67
Ramelton (Rozerem)
Novel Sedative-Hypnotic Melatonin receptor agonist - circadian sleep rhythms Short acting
68
Cyclobenzaprine (Flexeril)
H1 receptor antagonist Long acting SE of sedation used in tx of sleep disorders
69
Hydroxyzine (Atarax, Visteril)
H1 receptor antagonist Intermediate acting SE of sedation used in tx of sleep disorders
70
Diphenhydramine (Benadryl)
H1 receptor antagonist Short acting SE of sedation used in tx of sleep disorders
71
Valeriana officinalis
Herbal Preparation for sleep Sesquiterpenes are active compound: mediate GABA release and inhibit GABA breakdown
72
Chamomile (Matricaria recutita)
Herbal Preparation for sleep Benzodiazepine agonist Apigenin is active ingredient
73
Kava
Herbal Preparation for Sleep Facilitates binding of GABA Kaval lactones are active ingredient
74
Passion flower
Herbal Preparation for Sleep Benzodiazepine partial agonist Chrysin is active compound
75
Flumazenil (Romazicon)
Non-Benzodiazepine agonist Competes for BZ1 and BZ2, higher affinity than beznos, imidazopyradine, and pyrrolopyrazines Short acting
76
Thioridazine (Mellaril)
First Generation Antipsychotic Phenothiazine Low potency QTc prolongation!
77
Perphenazine (Trilafon)
First Generation Antipsychotic Phenothiazine Medium potency
78
Trifluoperazine (Stelazine)
First Generation Antipsychotic Phenothiazine High potency
79
Fluphenazine (Prolixin)
First Generation Antipsychotic Phenothiazine High potency
80
Thiothixene (Navane)
First Generation Antipsychotic Thiothixenes Medium potency
81
Cocaine
CNS stimulant Inhibits DA transporters, increases DA in synaptic cleft Tx with bromocriptine or benzos (lorazepam)
82
Amphetamines
``` Synthetic CNS stimulant Inhibits VMAT (filling of vesicles), leads to reversal of DAT and increases DA in synaptic cleft ``` Tx for asthma, narcolepsy, obesity
83
Bromocriptine
Dopamine agonist | Short term tx of cocaine withdrawal
84
Opioids
Morphine, codeine Semi-synthetic: heroin, hydromrophine (Dilaudid), oxycodone Synthetic: fentanyl (Sublimaze)
85
Naloxone (Narcan, Nalone)
m-opioid receptor antagonist with high affinity | Fast-acting tx of opioid overdose
86
Naltrexone (Vivitrol)
m-opioid receptor antagonist Tx of opioid and alcohol dependence Avoid giving with disulfiram, both are hepatotoxic
87
Methadone
m-opioid receptor agonist Has long t1/2 Prevents withdrawal symptoms and cravings
88
Buprenorphine
Partial m-opioid receptor agonist Tx of opioid withdrawal High affinity and slow dissociation Given with naloxone to decrease IV abuse
89
Dilsulfram
Alcohol aversion therapy Inhibits aldehyde dehydrogenase --> increased levels of acetaldehyde Causes nausea, dizziness, headache, hypotension, vomiting when patient drinks Least effective because patient will just stop taking it Hepatotoxic
90
Acamprosate
Tx for alcohol dependence Restores balance between neuronal excitation and inhibition Most effective Contraindicated in severe renal disease
91
Varenicline
Partial agonist of nicotinic ACh receptor Tx for nicotine dependence, relieves cravings/withdrwal symptoms Reduces pharmacologic reward from cigarette smoking

Pharmacology (44 decks)

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