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Pharmacology > Psych Drugs > Flashcards

Psych Drugs Flashcards

1
Q

Lithium

A

Anticonvulsant aka mood stabilizer

Bipolar Drug

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2
Q

Carbamazepine (Tegretol)

A

Anticonvulsant aka mood stabilizer
Bipolar Drug

No bipolar depression

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3
Q

Valproic Acid (Depakene and Depakote)

A

Anticonvulsant aka mood stabilizer
Bipolar Drug

No bipolar depression

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4
Q

Lamotrigine (Lamictal)

A

Anticonvulsant aka mood stabilizer
Bipolar Drug

No acute mania

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5
Q

Haloperidol (Haldol)

A

First Generation Antipsychotic
Butyrophenone
Bipolar Drug

High potency

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6
Q

Chlorpromazine (Thorazine)

A

First Generation Antipsychotic
Phenothiazine
Bipolar Drug

Low potency
First antipsychotic discovered

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7
Q

Risperidone (Risperdal)

A

Second Generation Antipsychotic

Bipolar Drug

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8
Q

Paliperidone (Invega)

A

Second Generation Antipsychotic

Bipolar Drug

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9
Q

Geodone (Ziprasidone)

A

Second Generation Antipsychotic
Bipolar Drug

No bipolar depression
QTc prolongation!

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10
Q

Iloperidone (Fanapt)

A

Second Generation Antipsychotic

Bipolar Drug

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11
Q

Lurasidone (Latuda)

A

Second Generation Antipsychotic

Bipolar Drug

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12
Q

Clozapine (Clozaril)

A

Second Generation Antipsychotic

Bipolar Drug

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13
Q

Olanzapine (Zyprexa)

A

Second Generation Antipsychotic

Bipolar Drug

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14
Q

Olanzapine + Fluoxetine (Symbyax)

A

Second Generation Antipsychotic + SSRI

Bipolar Drug

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15
Q

Quetiapine (Seroquel)

A

Second Generation Antipsychotic

Bipolar Drug

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16
Q

Asenapine (Saphris)

A

Second Generation Antipsychotic

Bipolar Drug

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17
Q

Aripiprazole (Abilify)

A

Second Generation Antipsychotic
Partial agonist
Bipolar Drug

No bipolar depression

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18
Q

Imipramine (Tofranil)

A

TCA
Tertiary

Long acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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19
Q

Amitriptyline (Elavil)

A

TCA
Tertiary

Long acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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20
Q

Desipramine (Norpramin)

A

TCA

Secondary

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21
Q

Nortriptyline (Pamelor)

A

TCA

Secondary

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22
Q

Clomipramine (Anafranil)

A

TCA

3 but act like 2

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23
Q

Doxepin (Sinequan)

A

TCA
3 but act like 2

Long acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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24
Q

Fluoxetine (Prozac)

A

SSRI

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25
Q

Paroxetine (Paxil)

A

SSRI

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26
Q

Sertraline (Zoloft)

A

SSRI

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27
Q

Fluvoxamine (Luvox)

A

SSRI

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28
Q

Citalopram (Celexa)

A

SSRI

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29
Q

Escitalopram (Lexapro)

A

SSRI

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30
Q

Duloxetine (Cymbalta)

A

SNRI

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31
Q

Venlafaxine (Effexor)

A

SNRI

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32
Q

Desvenlafaxine (Pristiq)

A

SNRI

Metabolite of Venlafaxine

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33
Q

Bupropion (Wellbutrin, Zyban)

A

Atypical Antidepressant
NE and DA reuptake inhibition

Welbutrin is antidepressant
Zyban reduces craving for nicotine

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34
Q

Mirtazapine (Remeron)

A

Atypical Antidepressant
a2 adrenergic receptor antagonist (increases NE and 5-HT)

Long acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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35
Q

Nefazodone (Serzone)

A

Atypical Antidepressant
5-HT2A antagonist and 5-HT reuptake inhibitor

Intermediate acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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36
Q

Trazodone (Deseryl)

A

Atypical Antidepressant
Blocks 5-HT2 and a1-adrenergic receptors

Intermediate acting
Anti-histaminergic action (aka sedation SE) used for sleep disorder

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37
Q

Vilazodone (Viibryd)

A

Atypical Antidepressant

5-HT reuptake inhibitor and 5-HT1A partial agonist

38
Q

Vortioxetine (Brintellix)

A

Atypical Antidepressant

5-HT reuptake inhibition and 5-HT1A full agonist

39
Q

Tranylcypromine

40
Q

Phenelzine

41
Q

Isocarboxazid

42
Q

Selegiline

A

MAOI (selective B)

43
Q

Moclobemide

A

Reversible MAOI

44
Q

Chlordiazepoxide (Librium)

A

Benzodiazepine

Long t1/2
Long acting
Metabolite is desmethyldiazepam

45
Q

Diazepam (Valium)

A

Benzodiazepine

Long t1/2
Long acting
Metabolite is desmethyldiazepam

46
Q

Flurazepam

A

Benzodiazepine

Long t1/2
Long acting
Approved for insomnia

47
Q

Flunitrazepam (Rohypnol)

A

Benzodiazepine

Long t1/2
aka Date Rape drug

48
Q

Clonazepam (Klonopin)

A

Benzodiazepine

Long t1/2

49
Q

Midazolam (Versed)

A

Benzodiazepine

Moderate t1/2
Short acting

50
Q

Alprazolam (Xanax)

A

Benzodiazepine

Moderate t1/2
Intermediate acting

51
Q

Triazolam (Halcion)

A

Benzodiazepine

Moderate t1/2
Short acting
Approved for insomnia, high abuse potential

52
Q

Lorazepam (Ativan)

A

Benzodiazepine

Short t1/2
Intermediate acting
Phase II only!
Not FDA approved for insomnia but commonly prescribed for it

53
Q

Oxazepam (Serax)

A

Benzodiazepine

Short t1/2
Intermediate acting
Phase II only!

54
Q

Temazepam (Restoril)

A

Benzodiazepine

Short t1/2
Phase II only!
Approved for insomnia

55
Q

Estazolam (ProSom)

A

Benzodiazepine

Intermediate acting
Approved for insomnia

56
Q

Chlorazepate (Tranxene)

A

Benzodiazepine

Long t1/2
Long acting
Metabolite is desmethyldiazepam

57
Q

Zolpidem (Ambien)

A

Selective Non-Benzodiazepine
Imidazopyridine

Short acting

58
Q

Zaleplon (Sonata)

A

Selective Non-Benzodiazepine
Imidazopyridine

Short acting

59
Q

Eszopiclone (Lunesta)

A

Selective Non-Benzodiazepine
Pyrrolopyrazine

Short acting

60
Q

Phenobarbital (Luminol Sodium)

A

Barbiturate

Long t1/2
Long acting

61
Q

Methohexital

A

Barbiturate

62
Q

Thiopental

A

Barbiturate

Short t1/2
Short acting

63
Q

Mexihexital

A

Barbiturate

Short t1/2

64
Q

Amobarbital (Amytal)

A

Barbiturate

Moderate t1/2

65
Q

Secobarbital (Seconal)

A

Barbiturate

Moderate t1/2

66
Q

Pentobarbital (Nembutal)

A

Barbiturate

Moderate t1/2
Long acting

67
Q

Ramelton (Rozerem)

A

Novel Sedative-Hypnotic
Melatonin receptor agonist - circadian sleep rhythms

Short acting

68
Q

Cyclobenzaprine (Flexeril)

A

H1 receptor antagonist

Long acting
SE of sedation used in tx of sleep disorders

69
Q

Hydroxyzine (Atarax, Visteril)

A

H1 receptor antagonist

Intermediate acting
SE of sedation used in tx of sleep disorders

70
Q

Diphenhydramine (Benadryl)

A

H1 receptor antagonist

Short acting
SE of sedation used in tx of sleep disorders

71
Q

Valeriana officinalis

A

Herbal Preparation for sleep

Sesquiterpenes are active compound: mediate GABA release and inhibit GABA breakdown

72
Q

Chamomile (Matricaria recutita)

A

Herbal Preparation for sleep
Benzodiazepine agonist

Apigenin is active ingredient

73
Q

Kava

A

Herbal Preparation for Sleep
Facilitates binding of GABA

Kaval lactones are active ingredient

74
Q

Passion flower

A

Herbal Preparation for Sleep
Benzodiazepine partial agonist

Chrysin is active compound

75
Q

Flumazenil (Romazicon)

A

Non-Benzodiazepine agonist
Competes for BZ1 and BZ2, higher affinity than beznos, imidazopyradine, and pyrrolopyrazines

Short acting

76
Q

Thioridazine (Mellaril)

A

First Generation Antipsychotic
Phenothiazine

Low potency
QTc prolongation!

77
Q

Perphenazine (Trilafon)

A

First Generation Antipsychotic
Phenothiazine

Medium potency

78
Q

Trifluoperazine (Stelazine)

A

First Generation Antipsychotic
Phenothiazine

High potency

79
Q

Fluphenazine (Prolixin)

A

First Generation Antipsychotic
Phenothiazine

High potency

80
Q

Thiothixene (Navane)

A

First Generation Antipsychotic
Thiothixenes

Medium potency

81
Q

Cocaine

A

CNS stimulant
Inhibits DA transporters, increases DA in synaptic cleft

Tx with bromocriptine or benzos (lorazepam)

82
Q

Amphetamines

A 
Synthetic CNS stimulant
Inhibits VMAT (filling of vesicles), leads to reversal of DAT and increases DA in synaptic cleft

Tx for asthma, narcolepsy, obesity

83
Q

Bromocriptine

A

Dopamine agonist

Short term tx of cocaine withdrawal

84
Q

Opioids

A

Morphine, codeine

Semi-synthetic: heroin, hydromrophine (Dilaudid), oxycodone

Synthetic: fentanyl (Sublimaze)

85
Q

Naloxone (Narcan, Nalone)

A

m-opioid receptor antagonist with high affinity

Fast-acting tx of opioid overdose

86
Q

Naltrexone (Vivitrol)

A

m-opioid receptor antagonist
Tx of opioid and alcohol dependence

Avoid giving with disulfiram, both are hepatotoxic

87
Q

Methadone

A

m-opioid receptor agonist
Has long t1/2
Prevents withdrawal symptoms and cravings

88
Q

Buprenorphine

A

Partial m-opioid receptor agonist
Tx of opioid withdrawal
High affinity and slow dissociation

Given with naloxone to decrease IV abuse

89
Q

Dilsulfram

A

Alcohol aversion therapy
Inhibits aldehyde dehydrogenase –> increased levels of acetaldehyde

Causes nausea, dizziness, headache, hypotension, vomiting when patient drinks
Least effective because patient will just stop taking it
Hepatotoxic

90
Q

Acamprosate

A

Tx for alcohol dependence
Restores balance between neuronal excitation and inhibition

Most effective
Contraindicated in severe renal disease

91
Q

Varenicline

A

Partial agonist of nicotinic ACh receptor
Tx for nicotine dependence, relieves cravings/withdrwal symptoms
Reduces pharmacologic reward from cigarette smoking

Pharmacology (44 decks)

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