AnemiaHematopoetic

Question 1

Oral Iron Therapy

Answer 1

Ferrous sulfate, ferrous gluconate, ferrous fumarate
Quick response, anemia reversed in 1-3 months
SE: nausea, vomiting, black stools

Question 2

Parenteral Iron Therapy (IM or IV)

Answer 2

Iron dextran, iron sucrose, iron gluconate
Indicated when oral is not tolerated, post GI resection, malabsorption
SE: pain, headache, fever, nausea, vomiting, allergic rxn,

Question 3

Erythropoietin therapy

Answer 3

Epoetin alfa, Epogen, Procrit, Aranesp
IV or subcu
Retics seen in around 10 days, Hgb in 2-6 weeks
SE: HTN, thrombotic complications, allergic reactions, tumor progression

Question 4

G-CSF and GM-CSF

Answer 4

Growth factors that stimulate proliferation and differentiation of myeloid cells
Filgrastim: recombinant human G-CSF
Pegfilgrastim: filgrastim conjugated to have longer half life
Sargramostim: recombinant human GM-CSF
Use for stem cell rescue/ stem cell release, leukemia
G-CSF is preferred

Question 5

IL-11

Answer 5

Produced by bone marrow
Promotes proliferation of megakaryocytic progenitors
Increases peripheral platelet counts

Question 6

Romiplostim

Answer 6

Peptibody
Peptide domain for TPO receptor
Antibody Fc domain to increase half-life
Tx: ITP
SE: Headache, myalgia, bone marrow fibrosis (reversible)

Question 7

Eltrombopag

Answer 7

Small molecule thrombopoietin-receptor agonist
Tx: ITP
SE: HEadache, myalgia, bone marrow fibrosis (reversible)
Good for aplastic anemia