Glycopeptides Flashcards

1
Q

Drugs

A
Vancomycin (use with MRSA and PRSP)
Teicoplanin
Dalbavancin
Telavancin
Oritavancin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Vanco MoA

A

Inhibits cell wall synthesis (different site than B-lactams)

Binds to D-alanyl-D-alanine portion of cell wall to prevent cross-linking

Time-dependent bactericidal activity; slowly kills bacteria (static against entero)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Vanco MoR

A

Resistance in VRE and VRSA from modification of D-alanyl-D-alanine binding site of peptidoglycan

VanA, vanB, vanC phenotypes

VISA (vanco intermediate s. aureus) has thickened cell wall, intermediate susceptibility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Vanco Pharmacology

A

Time-dependent bactericidal activity

Oral is no good (except for colitis), must use IV therapy for systemic infections

Widely distributed into body tissues, variable penetration into CSF (even with inflamed meninges)

TAKES 1 HR to distribute from plasma into tissue compartment

Eliminated unchanged by kidney, NOT removed by hemodialysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Vanco Adverse Effects

A

Red-Man Syndrome: flushing, pruritis, erythematous rash from high RATE of IV infusion, resolves spontaneously after discontinuation

Nephrotoxicity and Ototoxicity

Rash, neutropenia/thrombocytopenia, thrombophlebitis, interstitial nephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dalbavancin

A

2nd generation glycopeptide
Good for MRSA, VISA, VRE (vanB and vanC), MRSE, strepto, bacillus, listeria, corynebacter

Similar MoA to vanco, but more potent and cidal

Once/week dosing, IV only

Anaphylaxis, skin rxn, red man infusion, increased ALT, hematologic, head aches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Telavancin

A

MRSA and gram+s

Complicated SSSI, hospital acquired pneumonia, ventilatorAP (s.aureus)

AE: nausea/vomiting/constipation, headache, more renal toxicity than vanco

Be careful with pregnant women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Oritavancin

A

Semisynthetic glycopeptide for gram+s

MSSA, MRSA, entercoccus, strep, B.antracis

Disrupts cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly