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Pharmacology > Adrenergic Receptor Agonists/Antagonists > Flashcards

Adrenergic Receptor Agonists/Antagonists Flashcards

1
Q

Pre-ganglionic cells

A

Ach

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2
Q

Post-ganglionic parasympathetic release

A

Ach

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3
Q

Post-ganglionic sympathetic release

A

NE

EXCEPTION: Sweat glands and some skeletal/vascular smooth muscle release Ach

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4
Q

Adrenal gland releases

A

Epi and NE

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5
Q

Miosis

A

Pupillary CONSTRICTION

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6
Q

Mydriasis

A

Pupillary DILATION

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7
Q

Alpha 1

A

Vasoconstriction via PLC (DAG and IP3)

Contracts: Vascular smooth muscle, pupillary dilator muscle

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8
Q

Alpha 2

A

Inhibits NT release via Gi and inhibition of AC (no cAMP)
Vascoconstriction via inhibition of AC and PKA, increased affinity of MLCK to myosin light chain

Inhibtion of NT release, contracts some vascular smooth muscle

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9
Q

B1

A

Gs increases AC which phosphorylates Ca channels in pacemaker cells and myocytes

Stimulates rate and force of heart
Stimulates renin relase of juxtaglomerular cells

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10
Q

B2

A

Vasodilation via cAMP and PKA which phosphorylates MLCK to decrease its activity and inhibits myosin light chain

Relaxes respiratory, uterine, and vascular smooth muscle
Can cause tremor in voluntary muscle

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11
Q

Catecholamine receptor affinity

a1

A

Epi > NE&raquo_space;> Iso

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12
Q

Catecholamine receptor affinity

a2

A

Epi > NE&raquo_space;> Iso

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13
Q

Catecholamine receptor affinity

B1

A

Iso > Epi = NE

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14
Q

Catecholamine receptor affinity

B2

A

Iso > Epi&raquo_space; NE (not a full agonist)

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15
Q

Direct acting alpha agonist

Nonselective

A

Epi
Ne
Dopamine

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16
Q

Direct acting alpha agonist

a1 selective

A

Phenylephrine

17
Q

Direct acting alpha agonist

a2 selective

A

Clonidine

18
Q

Direct acting beta agonist

Nonselective

A

Epi

Isoproterenol

19
Q

Direct acting beta agonist

B1 selective

A

Ne
Dopamine
Dobutamine

20
Q

Direct acting beta agonist

B2 selective

A

Terbutaline

Albuterol

21
Q

Indirect acting agonist

Releasers and reuptake inhibitors

A 
Amphetamine
Methamphetamine
Methyphenidate
Ephedrine
Pseudoephedrine
Tyramine
22
Q

Adrenergic alpha antagonist

Nonselective

A

Phentolamine (reversible)

Phenoxybenzamine (irreversible)

23
Q

Adrenergic alpha antagonist

a1 selective

A

Prazosin
Dozazosin
Terazosin

24
Q

Adrenergic beta antagonists

Nonselective

A

Propanolol
Timolol
Nadolol

25
Q

Adrenergic beta antagonists

B1 selective

A

Atenolol

Metoprolol

26
Q

Adrenergic beta antagonists

Parial B1 and B2 agonist

A

Pindolol

Pharmacology (44 decks)

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