Lipopeptides

Question 1

Daptomycin

Answer 1

Cyclic lipopeptide with activity against resistant gram+ (VRE, MRSA, VISA)

Question 2

Daptomycin MoA

Answer 2

Binds to bacterial membranes, RAPID DEPOLARIZATION (Dap taps, and rap(idly) depolarizes), inhibition of protein, DNA, and RNA synthesis

Concentration-dependent bactericidal activity

Question 3

Daptomycin MoR

Answer 3

Rarely reported in VRE and MRSA due to altered cell membrane binding

Question 4

Daptomycin Pharmacology

Answer 4

Concentration-dependent bactericidal activity

IV

Readily distributed into well-perfused tissues, eliminated by kidneys, not eliminated by HD, needs dosage adjustment

Question 5

Daptomycin Clinical Uses

Answer 5

Very expensive

Reserved for serious/complicated infections caused by resistant bacteria

NOT USED IN TREATMENT OF PNEUMONIA. Inactivated by surfactant

Question 6

Synercid (Quinupristin-Dalfopristin)

Answer 6

Protein synthesis inhibitors (synergistic)

Liver clearance

AE: Severe GI intolerance