Sympathomimetics

Question 1

Epinephrine - receptor and Uses?

Answer 1

Alpha-1, Alpha 2, Beta-1, beta-2 agonist – used in cardiac arrest, anaphylaxis, local vasoconstriction and topically for local hemorrhage

Question 2

Norepinephrine- receptor and uses?

Answer 2

Agonist alpha-1 Alpha-2 and beta-1 – causes vasoconstriction and increased afterload

Question 3

Dopamine – receptor and uses?

Answer 3

In low dose Dopamine agonist that causes vasodilation, medium low doses beta-1 agonist causes positive inotrope, medium high dose Beta-1 agonist causes increased heart rate and high-dose beta-1 agonist causes vasoconstriction

Question 4

Dobutamine- receptor and uses?

Answer 4

Same as dopamine – synthetic Beta-1 agonist with minor beta-2 and alpha-1 agonist causes the same effects as dopamine. Used more in large animals especially for acute heart failure

Question 5

Isoproterenol- receptor and uses?

Answer 5

Nonspecific beta agonist causes positive inotropic effect and increased blood flow and bronchodilation – not used in veterinary medicine because of the strong

Question 6

Phenylephrine - receptor and uses?

Answer 6

Direct acting alpha-1 agonist causing increased peripheral vascular resistance used to treat hypertension and cats and dogs

Question 7

Selective beta-2 agonists

Answer 7

Albuterol, salbutamol, clenbuterol, terbutaline, isoxsuprine

Question 8

Albuterol/ Salbutamol- receptor and uses?

Answer 8

Used in inhalers

Question 9

Clenbuterol- receptor and uses?

Answer 9

Used for equine dystocia because it causes uterine relaxation

Question 10

Terbutaline -receptor and uses?

Answer 10

Used in small animal for bronchodilation

Question 11

Isoxsuprine -receptor and uses?

Answer 11

Used for bovine dystocia

Question 12

Nonselective beta agonist Ractopamine and Zilpaterol -receptor and uses?

Answer 12

Beta 3 agonist used for increased carcass leanness, feed efficiency, and increased deposition of muscle

Question 13

Indirect acting sympathomimetics

Answer 13

Clomipramine- serotonin agonist
Doxepin- serotonin agonist- antihistamine
Monoamine oxidase inhibitor- Selegiline- inhibits the reuptake of norepinephrine and breakdown

Question 14

Direct and indirect acting sympathomimetics

Answer 14

Phenylpropanolamine

Ephedrine

Question 15

Phenylpropanolamine -receptor and uses?

Answer 15

Direct alpha-1 agonist used to treat urinary incontinence due to urethral sphincter are incompetence

Question 16

Ephedrine -receptor and uses?

Answer 16

Direct alpha-1 and beta agonist used as a CRO to maintain blood pressure under anesthesia causes increased blood pressure, cardiac stimulation and bronchodilation

Question 17

Direct Acting Catecholamines

Answer 17

Epinephrine
norepinephrine
dopamine
dobutamine
isoproterenol
Phenylephrine