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RUSVM Pharmacology 2016 > Autocoids > Flashcards

Autocoids Flashcards

1
Q

H1 antagonist first-generation effects

A

Cross the blood brain barrier and have CNS depressant effects and anti-cholinergic effects

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2
Q

H1 antagonist second generation effects

A

Poor penetration of the blood brain barrier and exhibit noncompetitive/competitive antagonists

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3
Q

H 1 antagonist first generation and second-generation- receptor and uses?

A

Used for a local allergies, anaphylaxis, anti-motion sickness (anti emetics)

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4
Q

H2 antagonists

A

Cimetidine
Ranitidine
Famotidine
nizatidine

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5
Q

H2 antagonists- receptor and uses?

A

Competitive antagonist to H2 receptors - used for peptic ulcers, gastric erosive disease, gastric esophageal reflux disease, and duodenal ulcer

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6
Q

Cimetidine - receptor and uses?

A

Competitive H2 antagonist- used in equine melanoma

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7
Q

Ranitidine and Nizatidine - receptor and uses?

A

Competitive H2 antagonist- used as a prokinetic

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8
Q

Serotonin agonists

A

Cisapride

Fluoxetine

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9
Q

Cispride - receptor and uses?

A

Serotonin 4 receptor agonist used for prokinetic in colic and impaction

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10
Q

Fluoxetine - receptor and uses?

A

Selective serotonin reuptake inhibitor used as an antidepressant in the treatment of canine anxiety and for treatment of cats with inappropriate elimination or marking

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11
Q

Neurokinin antagonists

A

Miropitant Citrate (Cerenia)

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12
Q

Miropitant Citrate (Cerenia) - receptor and uses?

A

Blocks neurokinin 1 receptors used for the prevention of a acute vomiting due to motion sickness, viral infections, anticancer drugs

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13
Q

Prostaglandin inhibitors

A

Cyclooxygenase inhibitors: NSAIDs

phospholipase A2 inhibitors: corticosteroids

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14
Q

Janus kinase inhibitor- receptor and uses?

A

Inhibits pruritogenic and proinflammatory cytokines - used in the control of periodic allergic dermatitis and atopic dermatitis

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15
Q

Serotonin Antagonists

A

Cyproheptadine
Ondensetron
Metaclopramide
Mirtazapine

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16
Q

Cyproheptadine- receptor and uses?

A

Blocks H1 receptors and serotonin receptors - used as an antihistamine, stimulates appetite, and for the treatment of serotonin syndrome in dogs and cats

17
Q

Ondansetron- receptor and uses?

A

Inhibits serotonin receptor - used for the prevention and treatment of anti-cancer nausea and vomiting

18
Q

Metoclopramide - receptor and uses?

A

Serotonin 3 receptor antagonist and dopamine 1&2 antagonist - used as an antiemetic and prokinetic

19
Q

Mirtazapine - receptor and uses?

A

serotonin 2 & 3 receptor antagonist - used as an antidepressant( tricyclic antidepressant) and antiemetic

20
Q

Antihistamines

A

Drugs that competitively block histamine receptors H1 or H2

RUSVM Pharmacology 2016 (15 decks)

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