Immunosuppression and Chemo

Question 1

Cyclophosphamide - use?

Answer 1

Immune mediated hemolytic anemia

Question 2

Chlorambucil - use?

Answer 2

Inflammatory bowel disease

Question 3

Cystosine arabinoside - use?

Answer 3

Granulomatous meningoencephalitis

Question 4

Antimetabolites

Answer 4

Impair nuclear synthesis in a rapidly dividing immune cells and block signaling on T cells
Azathioprine
Mycophenoalate mofetil
Leflunomide

Question 5

Azathiprine- use?

Answer 5

Immunosuppression

Question 6

Mycophenolate mofetil - use?

Answer 6

Immune disease unresponsive to other therapies

Question 7

T cell inhibitors

Answer 7

Cyclosporine

Tacrolimus topical

Question 8

Cyclosporine - receptors and use?

Answer 8

Block cyclophillin/calcineurin which reduces T cell activation & response, inhibits production of various cytokines - used to treat keratoconjunctivitis sicca and perianal fistulas

Question 9

Tacrolimus topical - receptors and use?

Answer 9

Same as cyclosporine - used to treat dermatologic disease and perianal fistulas

Question 10

Chemotherapy drugs

Answer 10

Cyclophosphamide
Chlorambucil
Cytosine arabinoside