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RUSVM Pharmacology 2016 > GI Drugs > Flashcards

GI Drugs Flashcards

1
Q

Peripherally acting emetics

A

Hydrogen peroxide

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2
Q

Hydrogen peroxide

A

Direct irritation of oropharynx - for immediate treatment at home

do not use in cats!!

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3
Q

Centrally acting emetics

A

Apomorphine
Xylazine
Dexmedetomidine

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4
Q

Apomorphine - receptors and uses?

A

Stimulates dopamine receptors - centrally acting emetic in dogs

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5
Q

Xylazine and Dexmedetomadine - receptors and use?

A

Alpha -2 agonists - centrally acting emetic

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6
Q

Maropitant - receptor and uses?

A

Neurokinin 1 receptor antagonist - prevention of motion sickness and dogs and treatment of acute vomiting in dogs and cats

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7
Q

Metoclopramide- receptor and use?

A

Dopamine antagonist - antiemetic

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8
Q

Ondansetron - receptor and uses?

A

Serotonin antagonist - anticancer drug antiemetic

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9
Q

Antiulcer medications

A 
H2 blockers 
Proton pump inhibitors 
Oral antacids 
Prostaglandin analogs 
Gastroprotectants
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10
Q

H2 blockers

A

Cimetidine
Ranitidine
Famotidine

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11
Q

H2 blockers - receptor and uses?

A

Block H2 receptors for inhibition of gastric acid and pepsin secretion

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12
Q

Cimetidine - Fun Fact!

A

Inhibitor of hepatic microsomal enzymes

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13
Q

Omeprazole - receptor and uses?

A

Inhibits proton pump resulting in decreased hydrochloric acid production to raise gastric pH

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14
Q

Oral antacids - receptor and uses?

A

Inactivates Pepsin and binds to bile salts and stimulates prostaglandins, binds to phosphorus - used to chemically neutralize HCl

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15
Q

Prostaglandin analogs

A

Misoprostol

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16
Q

Misoprostol - receptor and uses?

A

Increases mucus and sodium bicarbonate secretion, stimulates epithelialization of the mucus and mucosal blood flow- treats NSAID induced gastric ulcers

17
Q

Sucralfulate

A

A sucrose aluminum compound that binds to the ulcer site and stimulates protective prostaglandins and antioxidants and increase mucosal blood flow - used to protect against acid, pepsin and bile

will inhibit the absorption of other drugs!!

18
Q

Drugs that induce gastric motility

A

Dopamine antagonists: metoclopromide &domperidone
Serotonin agonists- cisapride &mosapride
Ranitidine
Erythromycin
Lidocaine
Cholinergics

19
Q

Drugs that decrease gastric motility

A

Anticholinergics: Aminopentamide & atropine/glycopyrrolate
Opioids: loperamide
GI protectants and adsorbents

20
Q

GI protectants and adsorbents

A

Magnesium/aluminum products
Bismuth subsalicylate
Activated charcoal

21
Q

Stimulants of appetite

A

Norepinephrine (alpha -2)
Dopamine
GABA agonists

RUSVM Pharmacology 2016 (15 decks)

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