Switching_Antidepressants_Flashcards
What is the recommended approach for switching from citalopram, escitalopram, sertraline, or paroxetine to another SSRI?
When switching from citalopram, escitalopram, sertraline, or paroxetine to another SSRI, the first SSRI should be withdrawn before the alternative is started.
What is the recommended approach for switching from fluoxetine to another SSRI?
When switching from fluoxetine to another SSRI, withdraw fluoxetine and leave a gap of 4-7 days before starting a low-dose of the new SSRI.
What is the recommended approach for switching from an SSRI to a TCA?
When switching from an SSRI to a TCA, cross-tapering is recommended.
What is the exception when switching from an SSRI to a TCA?
The exception when switching from an SSRI to a TCA is that fluoxetine should be withdrawn before TCAs are started.
What is the recommended approach for switching from citalopram, escitalopram, sertraline, or paroxetine to venlafaxine?
When switching from citalopram, escitalopram, sertraline, or paroxetine to venlafaxine, cross-taper cautiously, starting venlafaxine at 37.5 mg OD and increasing very slowly.
What is the recommended approach for switching from fluoxetine to venlafaxine?
When switching from fluoxetine to venlafaxine, withdraw fluoxetine and then start venlafaxine at 37.5 mg OD, increasing very slowly.
Why does fluoxetine take longer to switch?
Fluoxetine takes longer to switch because it has a long half-life.
