Antipsychotics_Clozapine_Flashcards
What is clozapine used for in psychopharmacology?
Clozapine is used in treatment-resistant schizophrenia.
What is the mechanism of action of clozapine?
The mechanism of action of clozapine is blocking D1 and D4 receptors.
What are the contraindications for clozapine?
Contraindications for clozapine include previous or current neutropaenia, previous myocarditis, and active or progressive liver disease.
What are the common side effects of clozapine?
Common side effects of clozapine include sedation, weight gain, reduced seizure threshold, myocarditis, metabolic syndrome, hypersalivation, and gastrointestinal issues such as swallowing problems and constipation.
How does smoking cessation affect clozapine levels?
Smoking cessation can lead to a decrease in CYP450 activity, resulting in raised clozapine levels.
What patient monitoring services should clozapine patients be registered with?
Clozapine patients should be registered with the Clozaril patient monitoring service, Dezapine monitoring system, or Zaponex treatment access system.
What should be ensured before starting clozapine treatment?
Before starting clozapine treatment, ensure a normal leucocyte count and ECG.
What is the FBC monitoring schedule for clozapine?
The FBC monitoring schedule for clozapine is weekly for 18 weeks, fortnightly for 1 year, and monthly thereafter.
What are some severe side effects of clozapine?
Severe side effects of clozapine include agranulocytosis, neutropaenia, reduced seizure threshold, constipation, and myocarditis.
Why should a baseline ECG be taken before starting clozapine treatment?
A baseline ECG should be taken before starting clozapine treatment due to the risk of myocarditis.
