Suzuki Reaction Flashcards
1
Q
why popular
A
boronic acids are stable, cheap and environmentally friendly
2
Q
reagents
A
Pd(0) catalyst, boronic acid/ester, base, RX and R’X
3
Q
boronic esters or acids more reactive
A
acids
4
Q
reason for base
A
reacts with boronic acid/ester to form active ‘ate’ complex
5
Q
uses
A
coupling aryls to form biaryls to give sterically demanding products, stereoselective and conserved alkene geometry
6
Q
boronic acid/ester synthesis
A
hydroboration of alkynes or Li-halogen exchange, quench with B(OR)3, acid hydrolysis to boronic acid
7
Q
directed metallation groups
A
have lone pair electrons that interact with metal, influence reactions due to sterics
