Asymmetric Catalysis Flashcards
1
Q
sharpless asymmetric epoxidation reagents
A
allylic alcohol and Ti(OiPr)4, tBuOOH, L-(+)-DET gives diol with predictable stereochemistry
2
Q
Sharpless oxidation stereochemistry prediction
A
draw allylic alcohol in plane with OH in bottom right corner, [O] on top face if use L-(+)-DET and [O] on bottom face if use L-(-)-DET
3
Q
epoxyalcohols
A
strained 3-membered ring, undergo Sn2 ring opening
4
Q
LA catalysis
A
coordination of metal to LA decreases orbital energies including LUMO
5
Q
chelating ligands
A
lock substrate orientation
