Enantioselective Synthesis Flashcards
1
Q
Inducing chirality
A
Preform racemic synthesis then separate by resolution, chiron approach where start with enantiopure chiral compound and use diastereoselecive reactions, chiral auxiliarys and asymmetric catalysis
2
Q
diastereomeric excess
A
% of major diastereomer - % of minor diastereomer
3
Q
enantiomeric excess
A
% of major enantiomer - % of minor enantiomer
4
Q
measuring diastereomeric ratio
A
H NMR
5
Q
measuring enantiomeric ratio
A
CSP-GG of CSP-HPLC
6
Q
measuring enantiomeric excess
A
polarimetry
7
Q
max possible chemical yield when resolution approach used
A
50%
8
Q
resolution approach
A
treat racemic mixture with enantiopure compound
9
Q
prochiral molecules
A
substrates for asymmetric synthesis with enantiotopic faces/groups, reactions produce mixtures of enantiomers
