Gold Catalysis Flashcards
1
Q
characteristics of gold
A
carbophilic lewis acid, selective for pi-systems eg alkynes and alkenes
2
Q
Au(I)
A
bicoordinate and linear
3
Q
form cationic gold
A
more reactive, AuLCl + AgX gives L-Au+ X- and AgCl, where X is a weakly coordinating anion
4
Q
weakly coordinating anion
A
anion that doesn’t interfere with catalyst chemistry eg OTf or SbF6
5
Q
how gold catalysis works
A
coordinates to CC pi-bonds, removes electron density, bonds activated towards nucleophilic attack
6
Q
sterics of gold catalysis
A
gold adds to less hindered end and nucleophile adds anti
