Pd(II) Catalysed Reactions

Question 1

Wacker oxidation

Answer 1

oxidation of terminal alkene using PdCl2 (cat), H2O and CuCl2/O2 gives aldehyde/ketone

Question 2

use of CuCl2/O2 in Wacker

Answer 2

co-oxidants which re-oxidises PdCl2 to regenerate active catalytic species

Question 3

Saegusa oxidation

Answer 3

oxidation of aldehydes/ketones to a,b-unsaturated aldehydes/ketone using TMSCl and Pd(II) catalyst

Question 4

role of TMSCl in saegusa

Answer 4

forms silyl enol ether that tautomerises to give a good leaving group