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B11OQ > Sonogashira Reaction > Flashcards

Sonogashira Reaction Flashcards

1
Q

what C centre

A

sp

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2
Q

couples what with what

A

terminal alkynes with aryl/vinyl halides

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3
Q

Reactants

A

Pd(0) catalyst, RX, alkyne, CuI and Et2NH

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4
Q

role of CuI

A

reacts with alkyne to form CuR in situ which is the active transmetallation species

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5
Q

THP

A

tetrahydropyranyl, protecting group for OH

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B11OQ (27 decks)

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