Buchwald-Hartwig Cross Couplings Flashcards
1
Q
what is it
A
Pd(0) catalysed CN/CO bond formation, uses aryl halide and secondary amine with strong base
2
Q
requirements of Pd(0) catalyst
A
needs bulky bidentate ligands gives large bite angle that forces other ligands close together and promotes dissociation as they can’t adopt square planar geometry
3
Q
why specialist ligands on catalyst needed
A
unwanted side reaction with B-H elimination of not used
