Asymmetric Organocatalysis Flashcards
1
Q
macmillan’s postuate
A
for aldehydes/ketones, LUMO lowering can be used using LA coord or imine formation
2
Q
control of iminium ion geometry
A
sterics of gem-dimethyl clash with alkene
3
Q
regioselectivity
A
most +ve with most -ve
4
Q
enantioselectivity
A
geometry of iminium ion and bulky group blocking upper face
5
Q
diastereoselectivity
A
cis-endo rule
6
Q
CBS reduction of ketones
A
needs different sized R groups
